{"owner": "ArrayExpress Uploader", "ownerprofile_id": "arrayexpress_sid", "species": "mouse", "factors": [{"GSM958123": {"TREATMENT": "co-incubated with PDL1-overexpresssed ID8"}}, {"GSM958123": {"TREATMENT": "co-incubated with PDL1-overexpresssed ID8"}}, {"GSM958123": {"TREATMENT": "co-incubated with PDL1-overexpresssed ID8"}}, {"GSM958123": {"TREATMENT": "co-incubated with PDL1-overexpresssed ID8"}}, {"GSM958127": {"TREATMENT": "co-incubated with PDL1-depleted ID8"}}, {"GSM958127": {"TREATMENT": "co-incubated with PDL1-depleted ID8"}}, {"GSM958127": {"TREATMENT": "co-incubated with PDL1-depleted ID8"}}, {"GSM958127": {"TREATMENT": "co-incubated with PDL1-depleted ID8"}}], "id": 8635, "pop_total": 0, "platform": 8, "summary_wrapped": "Programmed cell death 1 ligand 1 (PD-L1) is known to suppress immune system and to be an unfavorable prognostic factor in ovarian cancer....", "geo_gse_id": "E-GEOD-39205", "owner_profile": "/profile/8773/arrayexpressuploader", "factor_count": 1, "sample_count": 8, "tags": ["cancer", "cell", "genome", "immune system", "ovarian cancer", "peritoneal cavity"], "lastmodified": "Dec.12, 2014", "is_default": false, "geo_gds_id": "", "slug": "gene-expression-profiles-of-pd-l1-affected-cd8-t-c", "geo_id_plat": "E-GEOD-39205_A-AFFY-36", "name": "Gene-expression profiles of PD-L1-affected CD8+ T cells", "created": "Nov.24, 2014", "summary": "Programmed cell death 1 ligand 1 (PD-L1) is known to suppress immune system and to be an unfavorable prognostic factor in ovarian cancer. The purpose of this study was to elucidate the function of PD-L1 in peritoneal dissemination. Tumor cell lysis by CTLs was attenuated when PD-L1 on tumor cells was overexpressed and promoted when it was silenced. PD-L1 overexpression also inhibited gathering and degranulation of CTLs. Gene expression profile of mouse CTLs caused by PD-L1-overexpressing ovarian cancer was related to human CTLs exhaustion. In mouse ovarian cancer dissemination models, depleting PD-L1 expression on tumor cells resulted in inhibited tumor growth in the peritoneal cavity and prolonged survival. Restoring immune function by inhibiting immune-suppressive factors such as PD-L1 may be a promising therapeutic strategy for peritoneal dissemination. Genome-wide transcriptional changes in OT-1 mouse CD8+ T cells that were co-incubated with OVA peptide-loaded ID8 mouse ovarian cancer cell lines. CTLs from 4 mice were devided into 2 groups, and co-incubated with PD-L1-overexpressed ID8 or PD-L1-depleted ID8.", "source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-39205", "sample_source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-39205/samples/"}