{"owner": "ArrayExpress Uploader", "ownerprofile_id": "arrayexpress_sid", "species": "human", "factors": [{"GSM958059": {"AGE": 68, "CYTOLOGY": "negative", "HISTOLOGY": "clear", "STAGE": "4"}}, {"GSM958060": {"AGE": 44, "CYTOLOGY": "negative", "HISTOLOGY": "clear", "STAGE": "1a"}}, {"GSM95806": {"AGE": 73, "CYTOLOGY": "negative", "HISTOLOGY": "undifferentiated", "STAGE": "3b"}}, {"GSM958062": {"AGE": 53, "CYTOLOGY": "negative", "HISTOLOGY": "clear", "STAGE": "1c"}}, {"GSM958063": {"AGE": 54, "CYTOLOGY": "negative", "HISTOLOGY": "endometrioid", "STAGE": "1c"}}, {"GSM958064": {"AGE": 54, "CYTOLOGY": "negative", "HISTOLOGY": "serous", "STAGE": "2a"}}, {"GSM958065": {"AGE": 75, "CYTOLOGY": "negative", "HISTOLOGY": "serous/clear", "STAGE": "3c"}}, {"GSM958066": {"AGE": 47, "CYTOLOGY": "negative", "HISTOLOGY": "mucinous", "STAGE": "1c"}}, {"GSM958067": {"AGE": 48, "CYTOLOGY": "negative", "HISTOLOGY": "clear", "STAGE": "1a"}}, {"GSM958068": {"AGE": 45, "CYTOLOGY": "negative", "HISTOLOGY": 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"serous", "STAGE": "3c"}}, {"GSM958062": {"AGE": 53, "CYTOLOGY": "negative", "HISTOLOGY": "clear", "STAGE": "1c"}}, {"GSM95808": {"AGE": 57, "CYTOLOGY": "negative", "HISTOLOGY": "serous", "STAGE": "3b"}}, {"GSM958082": {"AGE": 46, "CYTOLOGY": "negative", "HISTOLOGY": "endometrioid", "STAGE": "2c"}}, {"GSM958083": {"AGE": 58, "CYTOLOGY": "negative", "HISTOLOGY": "clear", "STAGE": "1a"}}, {"GSM958084": {"AGE": 61, "CYTOLOGY": "negative", "HISTOLOGY": "clear", "STAGE": "2a"}}, {"GSM958085": {"AGE": 48, "CYTOLOGY": "negative", "HISTOLOGY": "endometrioid", "STAGE": "2c"}}, {"GSM958086": {"AGE": 73, "CYTOLOGY": "negative", "HISTOLOGY": "serous", "STAGE": "1c"}}, {"GSM958087": {"AGE": 74, "CYTOLOGY": "negative", "HISTOLOGY": "serous", "STAGE": "3c"}}, {"GSM958088": {"AGE": 68, "CYTOLOGY": "negative", "HISTOLOGY": "clear", "STAGE": "1a"}}, {"GSM958089": {"AGE": 44, "CYTOLOGY": "negative", "HISTOLOGY": "endometrioid", "STAGE": "1a"}}, {"GSM958090": {"AGE": 52, "CYTOLOGY": "negative", "HISTOLOGY": "endometrioid", "STAGE": "1c"}}, {"GSM958082": {"AGE": 46, "CYTOLOGY": "negative", "HISTOLOGY": "endometrioid", "STAGE": "2c"}}, {"GSM958092": {"AGE": 53, "CYTOLOGY": "positive", "HISTOLOGY": "endometrioid", "STAGE": "1c"}}, {"GSM958093": {"AGE": 35, "CYTOLOGY": "positive", "HISTOLOGY": "serous", "STAGE": "3c"}}, {"GSM958094": {"AGE": 51, "CYTOLOGY": "positive", "HISTOLOGY": "serous", "STAGE": "3c"}}, {"GSM958095": {"AGE": 55, "CYTOLOGY": "positive", "HISTOLOGY": "serous", "STAGE": "3c"}}, {"GSM958096": {"AGE": 44, "CYTOLOGY": "positive", "HISTOLOGY": "clear", "STAGE": "3c"}}, {"GSM958097": {"AGE": 66, "CYTOLOGY": "positive", "HISTOLOGY": "serous", "STAGE": "3c"}}, {"GSM958098": {"AGE": 49, "CYTOLOGY": "positive", "HISTOLOGY": "serous", "STAGE": "4"}}, {"GSM958099": {"AGE": 45, "CYTOLOGY": "positive", "HISTOLOGY": "clear", "STAGE": "1c"}}, {"GSM958100": {"AGE": 58, "CYTOLOGY": "positive", "HISTOLOGY": "undifferentiated", "STAGE": "3c"}}, {"GSM95810": {"AGE": 47, "CYTOLOGY": "positive", "HISTOLOGY": "serous", "STAGE": "3c"}}, {"GSM958102": {"AGE": 64, "CYTOLOGY": "positive", "HISTOLOGY": "endometrioid", "STAGE": "1c"}}, {"GSM958103": {"AGE": 50, "CYTOLOGY": "positive", "HISTOLOGY": "endometrioid", "STAGE": "3b"}}, {"GSM958104": {"AGE": 55, "CYTOLOGY": "positive", "HISTOLOGY": "endometrioid", "STAGE": "3c"}}, {"GSM958105": {"AGE": 42, "CYTOLOGY": "positive", "HISTOLOGY": "serous", "STAGE": "3c"}}, {"GSM958106": {"AGE": 64, "CYTOLOGY": "positive", "HISTOLOGY": "serous", "STAGE": "3c"}}, {"GSM958107": {"AGE": 54, "CYTOLOGY": "positive", "HISTOLOGY": "serous", "STAGE": "2c"}}, {"GSM958108": {"AGE": 72, "CYTOLOGY": "positive", "HISTOLOGY": "serous", "STAGE": "3c"}}, {"GSM958093": {"AGE": 35, "CYTOLOGY": "positive", "HISTOLOGY": "serous", "STAGE": "3c"}}, {"GSM958110": {"AGE": 49, "CYTOLOGY": "positive", "HISTOLOGY": "serous", "STAGE": "3b"}}, {"GSM958": {"AGE": 40, "CYTOLOGY": "positive", "HISTOLOGY": "serous", "STAGE": "3c"}}, {"GSM958112": {"AGE": 55, "CYTOLOGY": "positive", "HISTOLOGY": "endometrioid", "STAGE": "3b"}}, {"GSM958113": {"AGE": 48, "CYTOLOGY": "positive", "HISTOLOGY": "serous", "STAGE": "3c"}}, {"GSM958114": {"AGE": 32, "CYTOLOGY": "positive", "HISTOLOGY": "clear", "STAGE": "4"}}, {"GSM958115": {"AGE": 81, "CYTOLOGY": "positive", "HISTOLOGY": "serous", "STAGE": "3c"}}, {"GSM958116": {"AGE": 50, "CYTOLOGY": "positive", "HISTOLOGY": "serous low grade", "STAGE": "3b"}}, {"GSM958117": {"AGE": 65, "CYTOLOGY": "positive", "HISTOLOGY": "serous", "STAGE": "4"}}, {"GSM958118": {"AGE": 56, "CYTOLOGY": "positive", "HISTOLOGY": "serous", "STAGE": "3c"}}, {"GSM958119": {"AGE": 59, "CYTOLOGY": "positive", "HISTOLOGY": "serous", "STAGE": "1c"}}, {"GSM958120": {"AGE": 46, "CYTOLOGY": "positive", "HISTOLOGY": "clear", "STAGE": "4"}}, {"GSM95812": {"AGE": 57, "CYTOLOGY": "positive", "HISTOLOGY": "endometrioid", "STAGE": "4"}}, {"GSM958094": {"AGE": 51, "CYTOLOGY": "positive", "HISTOLOGY": "serous", "STAGE": "3c"}}], "id": 4529, "pop_total": 0, "platform": 4, "summary_wrapped": "Ovarian cancer often progresses by disseminating to the peritoneal cavity, but how the tumor cells evade host immunity during this...", "geo_gse_id": "E-GEOD-39204", "owner_profile": "/profile/8773/arrayexpressuploader", "factor_count": 4, "sample_count": 64, "tags": ["cancer", "cell", "genome", "immune system", "ovarian cancer", "peritoneal cavity"], "lastmodified": "Dec.12, 2014", "is_default": false, "geo_gds_id": "", "slug": "gene-expression-profiles-of-ascites-cytology-posit", "geo_id_plat": "E-GEOD-39204_A-AFFY-44", "name": "Gene-expression profiles of ascites-cytology-positive ovarian cancer", "created": "Sep.19, 2014", "summary": "Ovarian cancer often progresses by disseminating to the peritoneal cavity, but how the tumor cells evade host immunity during this process is poorly understood. Programmed cell death 1 ligand 1 (PD-L1) is known to suppress immune system and to be an unfavorable prognostic factor in ovarian cancer. The purpose of this study was to elucidate the function of PD-L1 in peritoneal dissemination. Positive cytology in ascites was a significant poor prognostic factor in ovarian cancer. Microarray profiles of cytology-positive cases showed significant correlations with Gene Ontology terms related to immune system process. Microarray and immunohistochemistry in human ovarian cancer revealed significant correlation between PD-L1 expression and positive cytology. PD-L1 expression on mouse ovarian cancer cells was induced upon encountering lymphocytes in the course of peritoneal spread in vivo and upon co-culturing with lymphocytes in vitro. Tumor cell lysis by CTLs was attenuated when PD-L1 was overexpressed and promoted when it was silenced. PD-L1 overexpression also inhibited gathering and degranulation of CTLs. In mouse ovarian cancer dissemination models, depleting PD-L1 expression on tumor cells resulted in inhibited tumor growth in the peritoneal cavity and prolonged survival. Restoring immune function by inhibiting immune-suppressive factors such as PD-L1 may be a promising therapeutic strategy for peritoneal dissemination. Genome-wide transcriptional changes in human ovarian cancer tissue from ascites-cytology-positive or -negative patients.", "source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-39204", "sample_source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-39204/samples/"}