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"none", "DISEASE STATE": "healthy", "DAY": "not specified", "ETHNICITY": "Caucasian"}}, {"GSM955694": {"AGE": "42", "SEX": "male", "TREATMENT": "none", "DISEASE STATE": "healthy", "DAY": "not specified", "ETHNICITY": "Caucasian"}}, {"GSM955693": {"AGE": "19", "SEX": "female", "TREATMENT": "none", "DISEASE STATE": "healthy", "DAY": "not specified", "ETHNICITY": "Caucasian"}}, {"GSM955692": {"AGE": "23", "SEX": "male", "TREATMENT": "none", "DISEASE STATE": "healthy", "DAY": "not specified", "ETHNICITY": "Caucasian"}}, {"GSM95569": {"AGE": "39", "SEX": "female", "TREATMENT": "none", "DISEASE STATE": "healthy", "DAY": "not specified", "ETHNICITY": "Caucasian"}}, {"GSM955690": {"AGE": "41", "SEX": "female", "TREATMENT": "none", "DISEASE STATE": "healthy", "DAY": "not specified", "ETHNICITY": "Caucasian"}}, {"GSM955689": {"AGE": "35", "SEX": "female", "TREATMENT": "none", "DISEASE STATE": "healthy", "DAY": "not specified", "ETHNICITY": "Caucasian"}}, {"GSM955702": {"AGE": "37", "SEX": "female", "TREATMENT": "none", "DISEASE STATE": "healthy", "DAY": "not specified", "ETHNICITY": "Caucasian"}}, {"GSM955693": {"AGE": "19", "SEX": "female", "TREATMENT": "none", "DISEASE STATE": "healthy", "DAY": "not specified", "ETHNICITY": "Caucasian"}}, {"GSM955708": {"AGE": "34", "SEX": "female", "TREATMENT": "none", "DISEASE STATE": "healthy", "DAY": "not specified", "ETHNICITY": "Caucasian"}}, {"GSM955685": {"AGE": "44", "SEX": "female", "TREATMENT": "none", "DISEASE STATE": "healthy", "DAY": "not specified", "ETHNICITY": "Caucasian"}}, {"GSM955689": {"AGE": "35", "SEX": "female", "TREATMENT": "none", "DISEASE STATE": "healthy", "DAY": "not specified", "ETHNICITY": "Caucasian"}}, {"GSM955683": {"AGE": "40", "SEX": "female", "TREATMENT": "none", "DISEASE STATE": "healthy", "DAY": "not specified", "ETHNICITY": "Caucasian"}}, {"GSM955682": {"AGE": "38", "SEX": "female", "TREATMENT": "none", "DISEASE STATE": "healthy", "DAY": "not specified", "ETHNICITY": "Caucasian"}}, {"GSM95568": {"AGE": "21", "SEX": "female", "TREATMENT": "none", "DISEASE STATE": "healthy", "DAY": "not specified", "ETHNICITY": "Caucasian"}}, {"GSM955710": {"AGE": "41", "SEX": "male", "TREATMENT": "none", "DISEASE STATE": "healthy", "DAY": "not specified", "ETHNICITY": "Caucasian"}}], "id": 2704, "ownerprofile_id": "arrayexpress_sid", "platform": 4, "summary_wrapped": "We performed a phase I/II, randomized, double-blind, placebo-controlled dose-escalation study to examine the safety, immunogenicity, and...", "geo_gse_id": "E-GEOD-39088", "owner_profile": "/profile/8773/arrayexpressuploader", "factor_count": 6, "sample_count": 142, "tags": ["lupus erythematosus", "systemic lupus erythematosus"], "lastmodified": "Dec.12, 2014", "is_default": false, "geo_id_plat": "E-GEOD-39088_A-AFFY-44", "slug": "down-regulation-of-interferon-signature-in-systemi", "geo_gds_id": "", "name": "Down-regulation of Interferon signature in systemic lupus erythematosus patients by active immunization with Interferon alpha-Kinoid", "created": "Jul.12, 2014", "summary": "We performed a phase I/II, randomized, double-blind, placebo-controlled dose-escalation study to examine the safety, immunogenicity, and biological effects of active immunization with interferon alpha-Kinoid (IFN-K) in systemic lupus erythematosus (SLE) patients. Women 18-50 years of age with mild to moderate SLE were immunized with three (n=10) or four doses (n=9) of 30, 60, 120, 240 microgram IFN-K or saline. Anti-IFNalpha antibodies were detected in all IFN-K-immunized patients. Transcriptomic analysis separated patients at baseline into type I IFN signature-positive and -negative groups. IFN-K induced higher anti-IFNalpha titers in signature-positive than in signature-negative patients and, in signature-positive patients, reduced the expression of IFN-induced genes. The decrease in IFN score correlated with the anti-IFNalpha antibody titers, and with baseline IFN score. IFN-K or placebo was administered at day 0, day 7, day 28 in all patients. Half the subjects received a fourth injection at day 84 (see treatment protocol)", "source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-39088", "sample_source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-39088/samples/"}