ArrayExpress Uploaderarrayexpress_sidhuman1MSS.Young34.5maleMTumor2001-01-10Nonan2001-10-01WTWT1.00.042001-01-10left colonT4N2M1-1.0M02002-08-101MSS.Young36.4femaleWTTumor2000-05-31Nonan2000-05-31WTWT1.00.042000-05-31left colonT3N2M1-1.0WT02001-03-190MSS.Young36.9maleMnan2002-01-01No2002-01-012001-08-28WTWT1.01.02nanright colonT4N0M0-0.0WT02006-01-240MSS.Young38.2femaleMnannanNonan2001-06-29WTWT0.00.01nanleft colonT2N0M0-0.0WT02007-09-110MSS.Young38.8femaleWTnannanNonan2001-01-31WTWT0.00.01nanlow rectumT2N0M0-0.0M02009-02-231MSS.Young38.9femaleWTTumor2005-06-01Nonan1999-11-22WTWT1.00.042005-06-01multiple locationT3N0M1-1.0WT02009-03-081MSS.Young39.2femaleMTumor2002-08-22Nonan2002-07-22WTWT1.00.042004-09-06left colonT3N1M1-1.0WT02005-04-040MSI.Old60.9maleWTnannanHighnan2003-01-16WTWT0.00.03nanright colonT4N2M0-0.0WT12009-02-161MSI.Old78.2maleWTTumor2005-08-15High2005-08-152004-03-09WTWT1.01.02nanright colonT3N0M0-0.0WT12005-11-081MSS.Young45.0femaleWTTumor2002-08-07Nonan2000-02-29WTWT1.00.042002-08-07low rectumT3N2M1-1.0WT02002-11-011MSS.Young29.6femaleMTumor2004-10-13Nonan2004-10-13WTWT1.00.042004-10-13low rectumT3N2M1-1.0M02008-10-090MSS.Young33.5maleWTnannanNonan2003-03-06WTWT0.00.02nanlow rectumT3N0M0-0.0WT02009-02-160MSS.Young35.4femaleMnannanNonan2003-05-26WTM0.00.03nanleft colonT2N2M0-0.0WT02006-05-100MSS.Young37.5femaleWTnannanNonan2005-10-03WTM0.00.02nanleft colonT3N0M0-0.0M02008-07-240MSS.Young40.5femaleMnannanLownan2002-02-28WTM0.00.03nanleft colonT3N1M0-0.0M02007-06-261MSS.Young42.6maleWTTumornanNonan2001-06-12WTWTnannan2nanright colonT3N0M0-nanM02004-01-160MSS.Young43.5femaleMnannanNonan2001-02-01WTWT0.00.03nanlow rectumT3N1M0-0.0WT02009-01-130MSS.Young44.9femaleMnan2007-07-15Nonan1999-09-16WTWT1.00.02nanright colonT4N0M0-1.0M02009-02-130MSI.Young30.2maleWTnannanHighnan2002-03-01WTWT0.00.01nanleft colonT1N0M0-0.0WT12007-06-260MSI.Young31.7femaleWTnannanHighnan1999-12-02WTM0.00.01nanright colonT2N0M0-0.0M12007-02-230MSI.Young34.7femaleWTnannanHighnan1999-11-08WTM0.00.04nanright colonT4N2M1-0.0M12005-05-020MSI.Young40.2maleWTnannanHighnan2002-07-03WTM0.00.01nanleft colonT2N0M0-0.0WT12008-10-210MSS.Young24.9maleWTnannanNonan2003-04-16WTM0.00.02nanleft colonT3N0M0-0.0WT02007-02-270MSS.Young40.7femaleMnannanNonan2004-03-02WTWT0.00.04nanleft colonT4N1M1-0.0M02008-11-140MSS.Young41.9femaleWTnannanNonan2004-11-16WTM0.00.02nanleft colonT3N0M0-0.0WT02008-10-160MSS.Young45.2femaleMnannanLownan2005-04-18WTWT0.00.02nanleft colonT4N0M0-0.0WT02008-05-050MSI.Young40.8femaleWTnannanHighnan2004-06-11WTM0.00.03nanright colonT4N1M0-0.0M12008-07-290MSI.Old71.4femaleMnannanHighnan1999-11-30WTM0.00.01nanright colonT2N0M0nan0.0M02009-01-120MSI.Old66.4femaleWTnannanHighnan2004-02-25WTWT0.00.02nanright colonT3N0M0+0.0WT02008-08-050MSI.Old76.9maleWTnannanHighnan2004-01-29MWT0.00.03nanright colonT4N1M0+0.0WT02008-12-290MSI.Old81.8maleWTnannanHighnan2005-01-03WTWT0.00.02nanright colonT3N0M0-0.0M02009-01-141MSI.Old79.3maleMnannanHighnan2001-04-03WTM0.00.03nanright colonT4N2M0+0.0M02004-10-130MSI.Old75.3maleMnannanHighnan2001-05-23MWT0.00.03nanright colonT3N1M0+0.0WT02008-08-280MSI.Old68.0femaleWTnan2002-07-05High2002-07-052002-02-01MM1.01.02nanright colonT4N0M0+0.0WT02008-11-100MSS.Old66.6maleWTnannanNonan2005-11-16WTWT0.00.00nanright colonT0N0M0-0.0M02006-07-120MSS.Old66.3maleMnannanNonan2002-06-12WTWT0.00.02nanright colonT3N0M0-0.0WT02008-03-080MSS.Old66.7maleWTnannanNonan2003-05-09WTWT0.00.02nanright colonT3N0M0-0.0WT02009-02-021MSS.Old77.2femaleMTumor2006-07-15No2006-07-152005-03-25MWT1.01.042006-07-15right colonT4N1M1+1.0WT02006-10-151MSS.Old71.3maleWTTumor2006-10-25Nonan2005-06-15WTWT1.00.01nanright colonT2N0M0-1.0M02007-06-181MSS.Old83.1maleWTnannanNonan2005-09-30WTM0.00.01nanright colonT2N0M0+0.0M02006-10-211MSS.Old71.3maleMnannanNonan2002-01-07WTWT0.00.02nanleft colonT3N0M0-0.0WT02006-08-281MSS.Old72.5femaleMTumor2003-06-10Lownan2002-07-24WTWT1.00.022003-06-10low rectumT3N0M0-1.0M02007-07-241MSS.Old85.6maleWTnannanNonan2000-08-22WTWT0.00.02nanleft colonT4N0M0-0.0WT02002-05-230MSS.Old67.5maleWTnannanNonan2004-05-10WTWT0.00.02nanleft colonT3N0M0-0.0M02009-01-200MSS.Old80.9maleMnannanNonan2005-06-15WTWT0.00.02nanright colonT3N0M0-0.0WT02009-01-260MSS.Old70.7femaleWTnannanNonan2000-01-10WTWT0.00.02nanlow rectumT3N0M0+0.0M02008-02-280MSS.Old61.8femaleWTnannanNonan2005-12-08WTWT0.00.02nanleft colonT4N0M0-0.0WT02008-01-240MSS.Old63.0femaleWTnannanNonan2002-10-09WTWT0.00.03nanright colonT3N1M0-0.0WT02009-02-190MSS.Old72.0maleMnannanNonan2001-06-28MWT0.00.03nanright colonT3N2M0+0.0WT02008-12-011MSS.Old74.8maleWTTumor2003-01-07Nonan2001-06-27WTWT1.00.032003-01-07right colonT3N1M0-1.0M02003-06-011MSS.Old60.8maleMTumor2003-01-01Nonan2002-02-06WTWT1.00.032003-01-01low rectumT2N1M0-1.0WT02005-11-150MSS.Old61.5maleMnannanNonan2005-06-03WTWT0.00.03nanleft colonT3N1M0-0.0WT02005-07-210MSS.Old76.4femaleWTnan2002-10-23Nonan2002-01-10WTWT1.00.032002-10-23left colonT3N2M0-1.0WT02002-10-230MSS.Old71.5maleMnannanNonan1999-11-29WTWT0.00.03nanleft colonT2N1M0-0.0WT02006-01-020MSS.Old77.8maleMnan2008-02-12No2008-02-122005-12-29WTWT1.01.03nanleft colonT4N1M0-0.0M02008-03-041MSS.Old64.6maleWTTumor1999-09-22Nonan1999-09-22WTWT1.00.041999-09-22right colonT3N2M1-1.0M02002-01-070MSS.Old62.9femaleMnannanNonan2001-09-24WTWT0.00.04nanright colonT3N1M1-0.0M02009-02-230MSS.Old66.1maleMnan2005-06-07Nonan2005-06-07WTWT1.00.042005-06-07right colonT4N1M1-1.0M02009-02-161MSS.Old67.5femaleWTTumor2002-12-18Nonan2002-12-18WTM1.00.042002-12-18left colonT3N0M1-1.0WT02004-11-291MSS.Old71.0maleWTTumornanNonan2005-09-27MWT0.00.04nanright colonT4N2M1+0.0WT02005-11-301MSS.Old67.3maleMTumor2001-07-22No2001-07-222001-05-22MWT1.01.04nanleft colonT4N2M1+0.0WT02007-06-151MSS.Old67.8femaleMTumor2001-10-01Nonan2001-01-17WTWT1.00.042001-10-01left colonT4N2M1-1.0M02002-01-071MSS.Old68.1maleMTumor2001-01-18Nonan2001-05-18WTWT1.00.042001-01-18left colonT3N2M1-1.0M02002-04-171MSS.Old74.5maleWTTumor2003-07-10Nonan2002-09-05WTWT1.00.042004-06-18left colonT3N1M1-1.0M02006-08-041MSS.Old75.3femaleWTTumor2004-05-01Nonan2002-10-31MWT1.00.042004-05-01left colonT4N1M1+1.0WT02004-07-310MSS.Old86.8femaleWTnannanNonan1999-09-21WTWT0.00.04nanright colonT3N1M1-0.0M02008-03-061MSS.Old89.4femaleWTnannanNonan2001-07-19WTWT0.00.04nanleft colonT2N1M1-0.0WT02005-02-281MSS.Old65.8maleMTumor1999-05-06Nonan1999-05-06WTWT1.00.041999-05-06left colonT3N0M1-1.0WT02001-10-220MSI.Old92.4femaleWTnannanHighnan2001-03-02WTWT0.00.02nanleft colonT3N0M0+0.0M02008-10-231MSI.Old74.5femaleMTumor2004-02-15Highnan2002-11-28WTWT1.00.022004-02-15right colonT3N0M0-1.0WT12004-04-15452104Sporadic early onset colorectal carcinoma (EOCRC) is a growing problem that remains poorly understood. Clinical specificities and...25083765E-GEOD-39084/profile/8773/arrayexpressuploader2370carcinomaDec.12, 2014FalseE-GEOD-39084_A-AFFY-44sporadic-early-onset-colorectal-carcinoma-is-a-disSporadic early-onset colorectal carcinoma is a distinct clinicopathological and molecular entitySep.19, 2014Sporadic early onset colorectal carcinoma (EOCRC) is a growing problem that remains poorly understood. Clinical specificities and mechanisms of tumorigenesis might be relevant to both diagnosis and treatment. In this prospective study, clinicopathological features, genomic and gene expression profiles of sporadic EOCRC were compared to other well defined groups of CRC. Seventy selected patients were divided into 4 groups according to age (< 45 or > 60 years) and mismatch repair status. Mutations of key genes involved in colorectal carcinogenesis (P53, KRAS, BRAF, PIK3CA) were detected and the methylator phenotype (CIMP) established. Gene expression profiles (GEP) were obtained using pangenomic Affymetrix GeneChip.http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-39084http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-39084/samples/