Dataset: Sporadic early-onset colorectal carcinoma is a distinct clinicopathological and molecular entity
Sporadic early onset colorectal carcinoma (EOCRC) is a growing problem that remains poorly understood. Clinical specificities and...
Sporadic early onset colorectal carcinoma (EOCRC) is a growing problem that remains poorly understood. Clinical specificities and mechanisms of tumorigenesis might be relevant to both diagnosis and treatment. In this prospective study, clinicopathological features, genomic and gene expression profiles of sporadic EOCRC were compared to other well defined groups of CRC. Seventy selected patients were divided into 4 groups according to age (< 45 or > 60 years) and mismatch repair status. Mutations of key genes involved in colorectal carcinogenesis (P53, KRAS, BRAF, PIK3CA) were detected and the methylator phenotype (CIMP) established. Gene expression profiles (GEP) were obtained using pangenomic Affymetrix GeneChip.
- Species:
- human
- Samples:
- 70
- Source:
- E-GEOD-39084
- PubMed:
- 25083765
- Updated:
- Dec.12, 2014
- Registered:
- Sep.19, 2014
Factors:
(via ArrayExpress)
| Sample | DEATH | GROUP | AGE.YEAR | MSI.STATUS MISMATCH REPAIR STATUS | TP53.GENE.MUTATION.STATUS | DEATH.CAUSE | RELAPSE.DATE | SEX | RELAPSE.LOCAL.DATE | SURGERY.DATE | BRAF.GENE.MUTATION.STATUS | PIK3CA.GENE.MUTATION.STATUS | RELAPSE | RELAPSE.LOCAL | TNM.STAGE | RELAPSE.METASTASIS.DATE | TUMOR.LOCATION | TNM | CIMP.STATUS | RELAPSE.METASTASIS | KRAS.GENE.MUTATION.STATUS | LYNCH.SYNDROM | LASTNEWS OR DEATH.DATE |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| GSM955440 | 1 | MSS.Young | 34.5 | No | M | Tumor | 2001-01-10 | male | nan | 2001-10-01 | WT | WT | 1.0 | 0.0 | 4 | 2001-01-10 | left colon | T4N2M1 | - | 1.0 | M | 0 | 2002-08-10 |
| GSM95544 | 1 | MSS.Young | 36.4 | No | WT | Tumor | 2000-05-31 | female | nan | 2000-05-31 | WT | WT | 1.0 | 0.0 | 4 | 2000-05-31 | left colon | T3N2M1 | - | 1.0 | WT | 0 | 2001-03-19 |
| GSM955442 | 0 | MSS.Young | 36.9 | No | M | nan | 2002-01-01 | male | 2002-01-01 | 2001-08-28 | WT | WT | 1.0 | 1.0 | 2 | nan | right colon | T4N0M0 | - | 0.0 | WT | 0 | 2006-01-24 |
| GSM955443 | 0 | MSS.Young | 38.2 | No | M | nan | nan | female | nan | 2001-06-29 | WT | WT | 0.0 | 0.0 | 1 | nan | left colon | T2N0M0 | - | 0.0 | WT | 0 | 2007-09-11 |
| GSM955444 | 0 | MSS.Young | 38.8 | No | WT | nan | nan | female | nan | 2001-01-31 | WT | WT | 0.0 | 0.0 | 1 | nan | low rectum | T2N0M0 | - | 0.0 | M | 0 | 2009-02-23 |
| GSM955445 | 1 | MSS.Young | 38.9 | No | WT | Tumor | 2005-06-01 | female | nan | 1999-11-22 | WT | WT | 1.0 | 0.0 | 4 | 2005-06-01 | multiple location | T3N0M1 | - | 1.0 | WT | 0 | 2009-03-08 |
| GSM955446 | 1 | MSS.Young | 39.2 | No | M | Tumor | 2002-08-22 | female | nan | 2002-07-22 | WT | WT | 1.0 | 0.0 | 4 | 2004-09-06 | left colon | T3N1M1 | - | 1.0 | WT | 0 | 2005-04-04 |
| GSM955447 | 0 | MSI.Old | 60.9 | High | WT | nan | nan | male | nan | 2003-01-16 | WT | WT | 0.0 | 0.0 | 3 | nan | right colon | T4N2M0 | - | 0.0 | WT | 1 | 2009-02-16 |
| GSM955448 | 1 | MSI.Old | 78.2 | High | WT | Tumor | 2005-08-15 | male | 2005-08-15 | 2004-03-09 | WT | WT | 1.0 | 1.0 | 2 | nan | right colon | T3N0M0 | - | 0.0 | WT | 1 | 2005-11-08 |
| GSM955449 | 1 | MSS.Young | 45.0 | No | WT | Tumor | 2002-08-07 | female | nan | 2000-02-29 | WT | WT | 1.0 | 0.0 | 4 | 2002-08-07 | low rectum | T3N2M1 | - | 1.0 | WT | 0 | 2002-11-01 |
| GSM955450 | 1 | MSS.Young | 29.6 | No | M | Tumor | 2004-10-13 | female | nan | 2004-10-13 | WT | WT | 1.0 | 0.0 | 4 | 2004-10-13 | low rectum | T3N2M1 | - | 1.0 | M | 0 | 2008-10-09 |
| GSM95545 | 0 | MSS.Young | 33.5 | No | WT | nan | nan | male | nan | 2003-03-06 | WT | WT | 0.0 | 0.0 | 2 | nan | low rectum | T3N0M0 | - | 0.0 | WT | 0 | 2009-02-16 |
| GSM955452 | 0 | MSS.Young | 35.4 | No | M | nan | nan | female | nan | 2003-05-26 | WT | M | 0.0 | 0.0 | 3 | nan | left colon | T2N2M0 | - | 0.0 | WT | 0 | 2006-05-10 |
| GSM955453 | 0 | MSS.Young | 37.5 | No | WT | nan | nan | female | nan | 2005-10-03 | WT | M | 0.0 | 0.0 | 2 | nan | left colon | T3N0M0 | - | 0.0 | M | 0 | 2008-07-24 |
| GSM955454 | 0 | MSS.Young | 40.5 | Low | M | nan | nan | female | nan | 2002-02-28 | WT | M | 0.0 | 0.0 | 3 | nan | left colon | T3N1M0 | - | 0.0 | M | 0 | 2007-06-26 |
| GSM955455 | 1 | MSS.Young | 42.6 | No | WT | Tumor | nan | male | nan | 2001-06-12 | WT | WT | nan | nan | 2 | nan | right colon | T3N0M0 | - | nan | M | 0 | 2004-01-16 |
| GSM955456 | 0 | MSS.Young | 43.5 | No | M | nan | nan | female | nan | 2001-02-01 | WT | WT | 0.0 | 0.0 | 3 | nan | low rectum | T3N1M0 | - | 0.0 | WT | 0 | 2009-01-13 |
| GSM955457 | 0 | MSS.Young | 44.9 | No | M | nan | 2007-07-15 | female | nan | 1999-09-16 | WT | WT | 1.0 | 0.0 | 2 | nan | right colon | T4N0M0 | - | 1.0 | M | 0 | 2009-02-13 |
| GSM955458 | 0 | MSI.Young | 30.2 | High | WT | nan | nan | male | nan | 2002-03-01 | WT | WT | 0.0 | 0.0 | 1 | nan | left colon | T1N0M0 | - | 0.0 | WT | 1 | 2007-06-26 |
| GSM955459 | 0 | MSI.Young | 31.7 | High | WT | nan | nan | female | nan | 1999-12-02 | WT | M | 0.0 | 0.0 | 1 | nan | right colon | T2N0M0 | - | 0.0 | M | 1 | 2007-02-23 |
| GSM955460 | 0 | MSI.Young | 34.7 | High | WT | nan | nan | female | nan | 1999-11-08 | WT | M | 0.0 | 0.0 | 4 | nan | right colon | T4N2M1 | - | 0.0 | M | 1 | 2005-05-02 |
| GSM95546 | 0 | MSI.Young | 40.2 | High | WT | nan | nan | male | nan | 2002-07-03 | WT | M | 0.0 | 0.0 | 1 | nan | left colon | T2N0M0 | - | 0.0 | WT | 1 | 2008-10-21 |
| GSM955462 | 0 | MSS.Young | 24.9 | No | WT | nan | nan | male | nan | 2003-04-16 | WT | M | 0.0 | 0.0 | 2 | nan | left colon | T3N0M0 | - | 0.0 | WT | 0 | 2007-02-27 |
| GSM955463 | 0 | MSS.Young | 40.7 | No | M | nan | nan | female | nan | 2004-03-02 | WT | WT | 0.0 | 0.0 | 4 | nan | left colon | T4N1M1 | - | 0.0 | M | 0 | 2008-11-14 |
| GSM955464 | 0 | MSS.Young | 41.9 | No | WT | nan | nan | female | nan | 2004-11-16 | WT | M | 0.0 | 0.0 | 2 | nan | left colon | T3N0M0 | - | 0.0 | WT | 0 | 2008-10-16 |
| GSM955465 | 0 | MSS.Young | 45.2 | Low | M | nan | nan | female | nan | 2005-04-18 | WT | WT | 0.0 | 0.0 | 2 | nan | left colon | T4N0M0 | - | 0.0 | WT | 0 | 2008-05-05 |
| GSM955466 | 0 | MSI.Young | 40.8 | High | WT | nan | nan | female | nan | 2004-06-11 | WT | M | 0.0 | 0.0 | 3 | nan | right colon | T4N1M0 | - | 0.0 | M | 1 | 2008-07-29 |
| GSM955467 | 0 | MSI.Old | 71.4 | High | M | nan | nan | female | nan | 1999-11-30 | WT | M | 0.0 | 0.0 | 1 | nan | right colon | T2N0M0 | nan | 0.0 | M | 0 | 2009-01-12 |
| GSM955468 | 0 | MSI.Old | 66.4 | High | WT | nan | nan | female | nan | 2004-02-25 | WT | WT | 0.0 | 0.0 | 2 | nan | right colon | T3N0M0 | + | 0.0 | WT | 0 | 2008-08-05 |
| GSM955469 | 0 | MSI.Old | 76.9 | High | WT | nan | nan | male | nan | 2004-01-29 | M | WT | 0.0 | 0.0 | 3 | nan | right colon | T4N1M0 | + | 0.0 | WT | 0 | 2008-12-29 |
| GSM955470 | 0 | MSI.Old | 81.8 | High | WT | nan | nan | male | nan | 2005-01-03 | WT | WT | 0.0 | 0.0 | 2 | nan | right colon | T3N0M0 | - | 0.0 | M | 0 | 2009-01-14 |
| GSM95547 | 1 | MSI.Old | 79.3 | High | M | nan | nan | male | nan | 2001-04-03 | WT | M | 0.0 | 0.0 | 3 | nan | right colon | T4N2M0 | + | 0.0 | M | 0 | 2004-10-13 |
| GSM955472 | 0 | MSI.Old | 75.3 | High | M | nan | nan | male | nan | 2001-05-23 | M | WT | 0.0 | 0.0 | 3 | nan | right colon | T3N1M0 | + | 0.0 | WT | 0 | 2008-08-28 |
| GSM955473 | 0 | MSI.Old | 68.0 | High | WT | nan | 2002-07-05 | female | 2002-07-05 | 2002-02-01 | M | M | 1.0 | 1.0 | 2 | nan | right colon | T4N0M0 | + | 0.0 | WT | 0 | 2008-11-10 |
| GSM955474 | 0 | MSS.Old | 66.6 | No | WT | nan | nan | male | nan | 2005-11-16 | WT | WT | 0.0 | 0.0 | 0 | nan | right colon | T0N0M0 | - | 0.0 | M | 0 | 2006-07-12 |
| GSM955475 | 0 | MSS.Old | 66.3 | No | M | nan | nan | male | nan | 2002-06-12 | WT | WT | 0.0 | 0.0 | 2 | nan | right colon | T3N0M0 | - | 0.0 | WT | 0 | 2008-03-08 |
| GSM955476 | 0 | MSS.Old | 66.7 | No | WT | nan | nan | male | nan | 2003-05-09 | WT | WT | 0.0 | 0.0 | 2 | nan | right colon | T3N0M0 | - | 0.0 | WT | 0 | 2009-02-02 |
| GSM955477 | 1 | MSS.Old | 77.2 | No | M | Tumor | 2006-07-15 | female | 2006-07-15 | 2005-03-25 | M | WT | 1.0 | 1.0 | 4 | 2006-07-15 | right colon | T4N1M1 | + | 1.0 | WT | 0 | 2006-10-15 |
| GSM955478 | 1 | MSS.Old | 71.3 | No | WT | Tumor | 2006-10-25 | male | nan | 2005-06-15 | WT | WT | 1.0 | 0.0 | 1 | nan | right colon | T2N0M0 | - | 1.0 | M | 0 | 2007-06-18 |
| GSM955479 | 1 | MSS.Old | 83.1 | No | WT | nan | nan | male | nan | 2005-09-30 | WT | M | 0.0 | 0.0 | 1 | nan | right colon | T2N0M0 | + | 0.0 | M | 0 | 2006-10-21 |
| GSM955480 | 1 | MSS.Old | 71.3 | No | M | nan | nan | male | nan | 2002-01-07 | WT | WT | 0.0 | 0.0 | 2 | nan | left colon | T3N0M0 | - | 0.0 | WT | 0 | 2006-08-28 |
| GSM95548 | 1 | MSS.Old | 72.5 | Low | M | Tumor | 2003-06-10 | female | nan | 2002-07-24 | WT | WT | 1.0 | 0.0 | 2 | 2003-06-10 | low rectum | T3N0M0 | - | 1.0 | M | 0 | 2007-07-24 |
| GSM955482 | 1 | MSS.Old | 85.6 | No | WT | nan | nan | male | nan | 2000-08-22 | WT | WT | 0.0 | 0.0 | 2 | nan | left colon | T4N0M0 | - | 0.0 | WT | 0 | 2002-05-23 |
| GSM955483 | 0 | MSS.Old | 67.5 | No | WT | nan | nan | male | nan | 2004-05-10 | WT | WT | 0.0 | 0.0 | 2 | nan | left colon | T3N0M0 | - | 0.0 | M | 0 | 2009-01-20 |
| GSM955484 | 0 | MSS.Old | 80.9 | No | M | nan | nan | male | nan | 2005-06-15 | WT | WT | 0.0 | 0.0 | 2 | nan | right colon | T3N0M0 | - | 0.0 | WT | 0 | 2009-01-26 |
| GSM955485 | 0 | MSS.Old | 70.7 | No | WT | nan | nan | female | nan | 2000-01-10 | WT | WT | 0.0 | 0.0 | 2 | nan | low rectum | T3N0M0 | + | 0.0 | M | 0 | 2008-02-28 |
| GSM955486 | 0 | MSS.Old | 61.8 | No | WT | nan | nan | female | nan | 2005-12-08 | WT | WT | 0.0 | 0.0 | 2 | nan | left colon | T4N0M0 | - | 0.0 | WT | 0 | 2008-01-24 |
| GSM955487 | 0 | MSS.Old | 63.0 | No | WT | nan | nan | female | nan | 2002-10-09 | WT | WT | 0.0 | 0.0 | 3 | nan | right colon | T3N1M0 | - | 0.0 | WT | 0 | 2009-02-19 |
| GSM955488 | 0 | MSS.Old | 72.0 | No | M | nan | nan | male | nan | 2001-06-28 | M | WT | 0.0 | 0.0 | 3 | nan | right colon | T3N2M0 | + | 0.0 | WT | 0 | 2008-12-01 |
| GSM955489 | 1 | MSS.Old | 74.8 | No | WT | Tumor | 2003-01-07 | male | nan | 2001-06-27 | WT | WT | 1.0 | 0.0 | 3 | 2003-01-07 | right colon | T3N1M0 | - | 1.0 | M | 0 | 2003-06-01 |
| GSM955490 | 1 | MSS.Old | 60.8 | No | M | Tumor | 2003-01-01 | male | nan | 2002-02-06 | WT | WT | 1.0 | 0.0 | 3 | 2003-01-01 | low rectum | T2N1M0 | - | 1.0 | WT | 0 | 2005-11-15 |
| GSM95549 | 0 | MSS.Old | 61.5 | No | M | nan | nan | male | nan | 2005-06-03 | WT | WT | 0.0 | 0.0 | 3 | nan | left colon | T3N1M0 | - | 0.0 | WT | 0 | 2005-07-21 |
| GSM955492 | 0 | MSS.Old | 76.4 | No | WT | nan | 2002-10-23 | female | nan | 2002-01-10 | WT | WT | 1.0 | 0.0 | 3 | 2002-10-23 | left colon | T3N2M0 | - | 1.0 | WT | 0 | 2002-10-23 |
| GSM955493 | 0 | MSS.Old | 71.5 | No | M | nan | nan | male | nan | 1999-11-29 | WT | WT | 0.0 | 0.0 | 3 | nan | left colon | T2N1M0 | - | 0.0 | WT | 0 | 2006-01-02 |
| GSM955494 | 0 | MSS.Old | 77.8 | No | M | nan | 2008-02-12 | male | 2008-02-12 | 2005-12-29 | WT | WT | 1.0 | 1.0 | 3 | nan | left colon | T4N1M0 | - | 0.0 | M | 0 | 2008-03-04 |
| GSM955495 | 1 | MSS.Old | 64.6 | No | WT | Tumor | 1999-09-22 | male | nan | 1999-09-22 | WT | WT | 1.0 | 0.0 | 4 | 1999-09-22 | right colon | T3N2M1 | - | 1.0 | M | 0 | 2002-01-07 |
| GSM955496 | 0 | MSS.Old | 62.9 | No | M | nan | nan | female | nan | 2001-09-24 | WT | WT | 0.0 | 0.0 | 4 | nan | right colon | T3N1M1 | - | 0.0 | M | 0 | 2009-02-23 |
| GSM955497 | 0 | MSS.Old | 66.1 | No | M | nan | 2005-06-07 | male | nan | 2005-06-07 | WT | WT | 1.0 | 0.0 | 4 | 2005-06-07 | right colon | T4N1M1 | - | 1.0 | M | 0 | 2009-02-16 |
| GSM955498 | 1 | MSS.Old | 67.5 | No | WT | Tumor | 2002-12-18 | female | nan | 2002-12-18 | WT | M | 1.0 | 0.0 | 4 | 2002-12-18 | left colon | T3N0M1 | - | 1.0 | WT | 0 | 2004-11-29 |
| GSM955499 | 1 | MSS.Old | 71.0 | No | WT | Tumor | nan | male | nan | 2005-09-27 | M | WT | 0.0 | 0.0 | 4 | nan | right colon | T4N2M1 | + | 0.0 | WT | 0 | 2005-11-30 |
| GSM955500 | 1 | MSS.Old | 67.3 | No | M | Tumor | 2001-07-22 | male | 2001-07-22 | 2001-05-22 | M | WT | 1.0 | 1.0 | 4 | nan | left colon | T4N2M1 | + | 0.0 | WT | 0 | 2007-06-15 |
| GSM95550 | 1 | MSS.Old | 67.8 | No | M | Tumor | 2001-10-01 | female | nan | 2001-01-17 | WT | WT | 1.0 | 0.0 | 4 | 2001-10-01 | left colon | T4N2M1 | - | 1.0 | M | 0 | 2002-01-07 |
| GSM955502 | 1 | MSS.Old | 68.1 | No | M | Tumor | 2001-01-18 | male | nan | 2001-05-18 | WT | WT | 1.0 | 0.0 | 4 | 2001-01-18 | left colon | T3N2M1 | - | 1.0 | M | 0 | 2002-04-17 |
| GSM955503 | 1 | MSS.Old | 74.5 | No | WT | Tumor | 2003-07-10 | male | nan | 2002-09-05 | WT | WT | 1.0 | 0.0 | 4 | 2004-06-18 | left colon | T3N1M1 | - | 1.0 | M | 0 | 2006-08-04 |
| GSM955504 | 1 | MSS.Old | 75.3 | No | WT | Tumor | 2004-05-01 | female | nan | 2002-10-31 | M | WT | 1.0 | 0.0 | 4 | 2004-05-01 | left colon | T4N1M1 | + | 1.0 | WT | 0 | 2004-07-31 |
| GSM955505 | 0 | MSS.Old | 86.8 | No | WT | nan | nan | female | nan | 1999-09-21 | WT | WT | 0.0 | 0.0 | 4 | nan | right colon | T3N1M1 | - | 0.0 | M | 0 | 2008-03-06 |
| GSM955506 | 1 | MSS.Old | 89.4 | No | WT | nan | nan | female | nan | 2001-07-19 | WT | WT | 0.0 | 0.0 | 4 | nan | left colon | T2N1M1 | - | 0.0 | WT | 0 | 2005-02-28 |
| GSM955507 | 1 | MSS.Old | 65.8 | No | M | Tumor | 1999-05-06 | male | nan | 1999-05-06 | WT | WT | 1.0 | 0.0 | 4 | 1999-05-06 | left colon | T3N0M1 | - | 1.0 | WT | 0 | 2001-10-22 |
| GSM955508 | 0 | MSI.Old | 92.4 | High | WT | nan | nan | female | nan | 2001-03-02 | WT | WT | 0.0 | 0.0 | 2 | nan | left colon | T3N0M0 | + | 0.0 | M | 0 | 2008-10-23 |
| GSM955509 | 1 | MSI.Old | 74.5 | High | M | Tumor | 2004-02-15 | female | nan | 2002-11-28 | WT | WT | 1.0 | 0.0 | 2 | 2004-02-15 | right colon | T3N0M0 | - | 1.0 | WT | 1 | 2004-04-15 |