{"owner": "ArrayExpress Uploader", "ownerprofile_id": "arrayexpress_sid", "species": "human", "factors": [{"GSM340378": {"FSTL-1 NG/ML": "242", "SEX": "male", "RACE": "White", "TTF": "65min", "AGE_AT_ONSET": "LT6"}}, {"GSM340376": {"FSTL-1 NG/ML": "248", "SEX": "male", "RACE": "White", "TTF": "70min", "AGE_AT_ONSET": "GTE6"}}, {"GSM340375": {"FSTL-1 NG/ML": "218", "SEX": "female", "RACE": "White", "TTF": "120min", "AGE_AT_ONSET": "LT6"}}, {"GSM340372": {"FSTL-1 NG/ML": "311", "SEX": "female", "RACE": "White", "TTF": "140min", "AGE_AT_ONSET": "GTE6"}}, {"GSM34037": {"FSTL-1 NG/ML": "176", "SEX": "female", "RACE": "White", "TTF": "70min", "AGE_AT_ONSET": "LT6"}}, {"GSM340370": {"FSTL-1 NG/ML": "222", "SEX": "male", "RACE": "Black/African American", "TTF": "110min", "AGE_AT_ONSET": "LT6"}}, {"GSM340363": {"FSTL-1 NG/ML": "118", "SEX": "male", "RACE": "White", "TTF": "100min", "AGE_AT_ONSET": "GTE6"}}, {"GSM340362": {"FSTL-1 NG/ML": "159", "SEX": "male", "RACE": "White", "TTF": "120min", "AGE_AT_ONSET": "LT6"}}, {"GSM34036": {"FSTL-1 NG/ML": "176", "SEX": "male", "RACE": "Black/African American", "TTF": "135min", "AGE_AT_ONSET": "GTE6"}}, {"GSM340360": {"FSTL-1 NG/ML": "187", "SEX": "female", "RACE": "White", "TTF": "80min", "AGE_AT_ONSET": "LT6"}}, {"GSM340358": {"FSTL-1 NG/ML": "94", "SEX": "female", "RACE": "White", "TTF": "125min", "AGE_AT_ONSET": "GTE6"}}], "id": 2161, "pop_total": 0, "platform": 4, "summary_wrapped": "Objective. Follistatin-like protein 1 (FSTL-1) is a secreted glycoprotein that is over-expressed in certain inflammatory diseases.  Our...", "geo_gse_id": "E-GEOD-38849", "owner_profile": "/profile/8773/arrayexpressuploader", "factor_count": 5, "sample_count": 11, "tags": ["arthritis", "cell", "disease", "erythrocyte", "glycoprotein", "juvenile idiopathic arthritis", "macrophage", "peripheral", "protein", "serum", "syndrome"], "lastmodified": "Dec.12, 2014", "is_default": false, "geo_gds_id": "", "slug": "serum-follistatin-like-protein-1-is-a-biomarker-fo", "geo_id_plat": "E-GEOD-38849_A-AFFY-44", "name": "Serum Follistatin-Like Protein 1 Is a Biomarker for Macrophage Activation Syndrome and May Predict Disease Course in Systemic Juvenile Idiopathic Arthritis", "created": "Jul.11, 2014", "summary": "Objective. Follistatin-like protein 1 (FSTL-1) is a secreted glycoprotein that is over-expressed in certain inflammatory diseases.  Our objective in this study was to correlate FSTL-1 levels with measures of clinical disease activity in systemic juvenile idiopathic arthritis (sJIA), including macrophage activation syndrome (MAS). Methods. FSTL-1 serum levels were measured by ELISA in 28 patients with sJIA, including 7 patients who developed MAS, as well as in 30 normal controls.  Levels were correlated with erythrocyte sedimentation rate (ESR), ferritin and sIL-2R\u03b1 expression.  Differential gene expression based on FSTL-1 levels was analyzed in peripheral blood mononuclear cells (PBMCs). Results. FSTL-1 serum levels were elevated at time of presentation (pre-treatment) of sJIA (mean 200.7 ng/ml) and decreased to normal (mean 133.7 ng/ml) over 24 months (p<0.01). FSTL-1 levels were markedly elevated during acute MAS (mean 279.8 ng/ml) and decreased to normal (mean 120.3 ng/ml) following treatment (p<0.001).  FSTL-1 levels correlated with serum markers of inflammation, including sIL-2R\u03b1 and ferritin, in patients with MAS.  PBMCs from patients with FSTL-1 levels >200 ng/ml showed an increase in expression of genes related to innate immunity and erythropoiesis, and decrease in NK cell function.  Patients with the highest FSTL-1 levels at disease onset (>300 ng/ml) ultimately required cyclosporine treatment. Conclusion. In patients with sJIA, serum FSTL-1 is a biomarker for MAS and FSTL-1 levels at presentation may predict subsequent disease course.  Patients with FSTL-1 levels >200 ng/ml had altered gene expression patterns suggestive of subclinical MAS and may represent a subgroup of sJIA with more severe disease. FSTL-1 serum levels were measured by ELISA in 28 patients with sJIA, including 7 patients who developed MAS, as well as in 30 normal controls.  Levels were correlated with erythrocyte sedimentation rate (ESR), ferritin and sIL-2R\u03b1 expression.  Differential gene expression based on FSTL-1 levels was analyzed in peripheral blood mononuclear cells (PBMCs). Only 11 patients were run on microarray.", "source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-38849", "sample_source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-38849/samples/"}