{"owner": "ArrayExpress Uploader", "pop_total": 0, "id": 6894, "factors": [{"GSM935732": {"DIET": "AIN93G diet for 14 days"}}, {"GSM935732": {"DIET": "AIN93G diet for 14 days"}}, {"GSM935732": {"DIET": "AIN93G diet for 14 days"}}, {"GSM935732": {"DIET": "AIN93G diet for 14 days"}}, {"GSM935732": {"DIET": "AIN93G diet for 14 days"}}, {"GSM935737": {"DIET": "STZ-treated fed AIN93G diet for 14 days"}}, {"GSM935737": {"DIET": "STZ-treated fed AIN93G diet for 14 days"}}, {"GSM935737": {"DIET": "STZ-treated fed AIN93G diet for 14 days"}}, {"GSM935737": {"DIET": "STZ-treated fed AIN93G diet for 14 days"}}, {"GSM935737": {"DIET": "STZ-treated fed AIN93G diet for 14 days"}}, {"GSM935742": {"DIET": "STZ-treated and AIN93G diet with 0.1% phloridzin for 14 days"}}, {"GSM935742": {"DIET": "STZ-treated and AIN93G diet with 0.1% phloridzin for 14 days"}}, {"GSM935742": {"DIET": "STZ-treated and AIN93G diet with 0.1% phloridzin for 14 days"}}, {"GSM935742": {"DIET": "STZ-treated and AIN93G diet with 0.1% phloridzin for 14 days"}}, {"GSM935742": {"DIET": "STZ-treated and AIN93G diet with 0.1% phloridzin for 14 days"}}, {"GSM935747": {"DIET": "STZ-treated and AIN93G diet with 0.5% phloridzin for 14 days"}}, {"GSM935747": {"DIET": "STZ-treated and AIN93G diet with 0.5% phloridzin for 14 days"}}, {"GSM935747": {"DIET": "STZ-treated and AIN93G diet with 0.5% phloridzin for 14 days"}}, {"GSM935747": {"DIET": "STZ-treated and AIN93G diet with 0.5% phloridzin for 14 days"}}, {"GSM935747": {"DIET": "STZ-treated and AIN93G diet with 0.5% phloridzin for 14 days"}}], "ownerprofile_id": "arrayexpress_sid", "platform": 6, "summary_wrapped": "Phloridzin is a dihydrochalcone typically contained in apples. A diet containing 0.5 % phloridzin significantly improves hyperglycemia...", "pubmed_id": 19413312, "geo_gse_id": "E-GEOD-38138", "owner_profile": "/profile/8773/arrayexpressuploader", "factor_count": 1, "sample_count": 20, "tags": ["glucose", "hyperglycemia", "intestine", "lipid", "small intestine"], "lastmodified": "Dec.12, 2014", "is_default": false, "geo_gds_id": "", "slug": "hepatic-gene-expression-in-streptozotocin-induce-2", "geo_id_plat": "E-GEOD-38138_A-AFFY-45", "name": "Hepatic gene expression in streptozotocin-induced diabetic mice fed a phloridzin diet", "created": "Nov.12, 2014", "summary": "Phloridzin is a dihydrochalcone typically contained in apples. A diet containing 0.5 % phloridzin significantly improves hyperglycemia but not hypoinsulinemia and tissue lipid peroxidation in streptozotocin (STZ)-induced diabetic mice after 14 days. The phloridzin diet has no effect on the alteration of hepatic gene expression in STZ-induced diabetic mice. A quantitative RT-PCR analysis showed a reversal of the STZ induction of the sodium/glucose cotransporter gene Sglt1 and the drug-metabolizing enzyme genes Cyp2b10 and Ephx1 in the small intestine of mice fed a 0.5% phloridzin diet. These mice also showed a reversal of the STZ-mediated renal induction of the glucose-regulated facilitated glucose transporter gene Glut2. Dietary phloridzin improved the abnormal elevations in blood glucose level and the overexpression of Sglt1, Cyp2b10 and Ephx1 in the small intestine of STZ-induced diabetic mice. Six-week-old male mice were divided into 4 groups of 6 mice each, housed in groups of 3 per cage. After 1 week mice were intraperitoneally injected with STZ.  Mice (n=6) in the untreated control group did not receive any treatment. After 1 week, 18 mice showing non-fasting blood glucose levels of 330-590 mg/dL were divided into 3 groups: one group was fed with AIN93G only (control group), the others with an AIN93G diet containing 0.1% or 0.5% phloridzin (Funakoshi, Tokyo, Japan) for 2 weeks.", "source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-38138", "species": "mouse", "sample_source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-38138/samples/"}