{"owner": "ArrayExpress Uploader", "pop_total": 0, "id": 6893, "factors": [{"GSM935660": {"diet": "control"}}, {"GSM935660": {"diet": "control"}}, {"GSM935660": {"diet": "control"}}, {"GSM935660": {"diet": "control"}}, {"GSM935660": {"diet": "control"}}, {"GSM935660": {"diet": "control"}}, {"GSM935666": {"diet": "0.1% quercetin diet"}}, {"GSM935666": {"diet": "0.1% quercetin diet"}}, {"GSM935666": {"diet": "0.1% quercetin diet"}}, {"GSM935666": {"diet": "0.1% quercetin diet"}}, {"GSM935666": {"diet": "0.1% quercetin diet"}}, {"GSM935666": {"diet": "0.1% quercetin diet"}}, {"GSM935672": {"diet": "0.5% quercetin diet"}}, {"GSM935672": {"diet": "0.5% quercetin diet"}}, {"GSM935672": {"diet": "0.5% quercetin diet"}}, {"GSM935672": {"diet": "0.5% quercetin diet"}}, {"GSM935672": {"diet": "0.5% quercetin diet"}}, {"GSM935672": {"diet": "0.5% quercetin diet"}}, {"GSM935678": {"diet": "1.0% quercetin diet"}}, {"GSM935678": {"diet": "1.0% quercetin diet"}}, {"GSM935678": {"diet": "1.0% quercetin diet"}}, {"GSM935678": {"diet": "1.0% quercetin diet"}}, {"GSM935678": {"diet": "1.0% quercetin diet"}}, {"GSM935678": {"diet": "1.0% quercetin diet"}}], "ownerprofile_id": "arrayexpress_sid", "platform": 6, "summary_wrapped": "We showed that diets containing 0.1% or 0.5% quercetin lowered the STZ-induced increase in blood glucose levels and improved plasma...", "pubmed_id": 19496084, "geo_gse_id": "E-GEOD-38136", "owner_profile": "/profile/8773/arrayexpressuploader", "factor_count": 1, "sample_count": 24, "tags": ["glucose", "insulin"], "lastmodified": "Dec.12, 2014", "is_default": false, "geo_gds_id": "", "slug": "hepatic-gene-expression-in-balbc-mice-fed-a-querce", "geo_id_plat": "E-GEOD-38136_A-AFFY-45", "name": "Hepatic gene expression in BALB/c mice fed a quercetin diet", "created": "Nov.12, 2014", "summary": "We showed that diets containing 0.1% or 0.5% quercetin lowered the STZ-induced increase in blood glucose levels and improved plasma insulin levels.  A cluster analysis of the hepatic gene expressions showed that 0.5% quercetin diet suppressed STZ-induced alteration of gene expression.  Gene set enrichment analysis (GSEA) and quantitative RT-PCR analysis showed that the quercetin diets had their greatest suppressive effect on the STZ-induced elevation of expression of cyclin dependent kinase inhibitor p21(WAF1/Cip1) (Cdkn1a). In this experiment, we determined the effect of quercetin on healthy control BALB/c mice that were fed the AIN93G diet containing 0, 0.1, 0.5 or 1% quercetin for 2 weeks. GSEA and one-way ANOVA did not detect any significant changes in hepatic gene expression in normal mice as a result of a quercetin diet.  Using a linear modeling approach and the empirical Bayes statistics, we found that Ubc were significantly reduced by both the 0.5% and 1% quercetin. Six-week-old male mice were divided into 4 groups of 6 mice each, housed in groups of 3 per cage, and fed a standard purified AIN-93G diet containing 0% (Control), 0.1% (0.1), 0.5% (0.5), or 1% quercertin  (1.0) for 2 weeks.", "source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-38136", "species": "mouse", "sample_source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-38136/samples/"}