{"owner": "ArrayExpress Uploader", "ownerprofile_id": "arrayexpress_sid", "species": "mouse", "factors": [{"GSM933351 1": {}}, {"GSM933352 1": {}}, {"GSM933353 1": {}}, {"GSM933354 1": {}}, {"GSM933355 1": {}}, {"GSM933356 1": {}}, {"GSM933357 1": {}}, {"GSM933358 1": {}}, {"GSM933359 1": {}}, {"GSM933360 1": {}}, {"GSM933361 1": {}}, {"GSM933362 1": {}}, {"GSM933363 1": {}}, {"GSM933364 1": {}}, {"GSM933365 1": {}}, {"GSM933366 1": {}}, {"GSM933367 1": {}}, {"GSM933368 1": {}}, {"GSM933369 1": {}}, {"GSM933370 1": {}}, {"GSM933371 1": {}}, {"GSM933372 1": {}}, {"GSM933373 1": {}}, {"GSM933374 1": {}}], "id": 6890, "pop_total": 0, "platform": 6, "summary_wrapped": "Quercetin is a food component that may ameliorate the diabetic symptoms.  We examined hepatic gene expression of BALB/c mice with...", "pubmed_id": 19496084, "geo_gse_id": "E-GEOD-38067", "owner_profile": "/profile/8773/arrayexpressuploader", "factor_count": 0, "sample_count": 24, "tags": ["glucose", "insulin", "liver"], "lastmodified": "Dec.12, 2014", "is_default": false, "geo_id_plat": "E-GEOD-38067_A-AFFY-45", "slug": "hepatic-gene-expression-in-streptozotocin-induced", "geo_gds_id": "", "name": "Hepatic gene expression in streptozotocin-induced diabetic mice fed a quercetin diet", "created": "Nov.12, 2014", "summary": "Quercetin is a food component that may ameliorate the diabetic symptoms.  We examined hepatic gene expression of BALB/c mice with streptozotocin (STZ)-induced diabetes to elucidate the mechanism of the protective effect of dietary quercetin on diabetes-associated liver injury. We fed STZ-induced diabetic mice with diets containing 0.1% or 0.5% quercetin for 2 weeks and compared the patterns of hepatic gene expression in these groups of mice using a DNA microarray. Diets containing 0.1% or 0.5% quercetin lowered the STZ-induced increase in blood glucose levels and improved plasma insulin levels. A cluster analysis of the hepatic gene expressions showed that 0.5% quercetin diet suppressed STZ-induced alteration of gene expression.  Gene set enrichment analysis (GSEA) and quantitative RT-PCR analysis showed that the quercetin diets had their greatest suppressive effect on the STZ-induced elevation of expression of cyclin dependent kinase inhibitor p21(WAF1/Cip1) (Cdkn1a). Six-week-old male mice were divided into 4 groups of 6 mice each, housed in groups of 3 per cage. After 1 week mice were intraperitoneally injected with STZ.  Mice (n=6) in the untreated control group did not receive any treatment. After 1 week, 18 mice showing non-fasting blood glucose levels of 230-400 mg/dL were divided into 3 groups: one group was fed with AIN93G only (control group), the others with an AIN93G diet containing 0.1% or 0.5% quercetin (Funakoshi, Tokyo, Japan) for 2 weeks.", "source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-38067", "sample_source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-38067/samples/"}