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Here, we show that...", "geo_gse_id": "E-GEOD-37946", "owner_profile": "/profile/8773/arrayexpressuploader", "factor_count": 5, "sample_count": 50, "tags": ["breast", "breast cancer", "cancer", "cell"], "lastmodified": "Dec.12, 2014", "is_default": false, "geo_id_plat": "E-GEOD-37946_A-AFFY-33", "slug": "her2-enriched-tumor-initiating-cell-htic-genomic-p", "geo_gds_id": "", "name": "HER2-enriched tumor initiating cell (HTIC) genomic predictor of response following neoadjuvant trastuzumab-based chemotherapy in HER2+ breast cancer", "created": "Jun.18, 2014", "summary": "We identified a 17-gene Her2-enriched tumor initiating cell (HTIC) signature in MMTV-Her2/Neu mouse mammary TICs. Here, we show that patients with HTICS+ HER2+:ER\u03b1\u2212 tumors are more likely to achieve a pathologic complete response to trastuzumab-based neoadjuvant chemotherapy compared with HER2+:ER+ tumors. Neoadjuvant study of 50 HER2-positive breast cancer cases treated with trastuzumab-based chemotherapy pre-operatively. Pre-treatment FNA from primary tumors were obtained and RNA extracted and hybridized to Affymetrix microarrays according to manufacturer protocol. Pathologic response was assessed at the end of neoadjuvant treatment.", "source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-37946", "sample_source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-37946/samples/"}