{"owner": "ArrayExpress Uploader", "pop_total": 0, "id": 6881, "factors": [{"GSM688705": {"MAX EXPRESSION": "not specified", "STRAIN OR LINE": "129SV"}}, {"GSM688705": {"MAX EXPRESSION": "not specified", "STRAIN OR LINE": "129SV"}}, {"GSM929906": {"MAX EXPRESSION": "yes", "STRAIN OR LINE": "129sv"}}, {"GSM929907": {"MAX EXPRESSION": "no", "STRAIN OR LINE": "129sv"}}], "ownerprofile_id": "arrayexpress_sid", "platform": 6, "summary_wrapped": "Ablation of expression of the Max gene encoding a Myc protein partner in ES cells provoked two major phenomena, i.e. loss of pluripotency...", "pubmed_id": 22696478, "geo_gse_id": "E-GEOD-37917", "owner_profile": "/profile/8773/arrayexpressuploader", "factor_count": 2, "sample_count": 4, "tags": ["cell", "protein"], "lastmodified": "Dec.12, 2014", "is_default": false, "geo_gds_id": "", "slug": "sirt1-p53-and-p38mapk-are-crucial-regulators-of-de", "geo_id_plat": "E-GEOD-37917_A-AFFY-45", "name": "Sirt1, p53 and p38MAPK are crucial regulators of detrimental phenotypes of ESCs with Max expression ablation", "created": "Nov.12, 2014", "summary": "Ablation of expression of the Max gene encoding a Myc protein partner in ES cells provoked two major phenomena, i.e. loss of pluripotency and apoptotic cell death. We found that nicotinamide (Nam) significantly alleviates these Max expression ablation-coupled phenotypes in ES cells. To see the alleviation effect of Nam on the overall expression profile of Max-null ES cells whose Max expression is controlled by the tet-off system, we eliminated Max expression by adding doxycycline (Dox) in the presence of Nam. DNA microarray analyses were performed using total RNAs from Nam (4 mM)-treated Max-null ES cells that were cultured in the presence or absence of doxycycline for 6 days.", "source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-37917", "species": "mouse", "sample_source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-37917/samples/"}