{"owner": "ArrayExpress Uploader", "pop_total": 0, "id": 8624, "factors": [{"GSM929282": {"GENOTYPE": "wildtype", "COMPOUND": "vehicle (saline)"}}, {"GSM929282": {"GENOTYPE": "wildtype", "COMPOUND": "vehicle (saline)"}}, {"GSM929282": {"GENOTYPE": "wildtype", "COMPOUND": "vehicle (saline)"}}, {"GSM929285": {"GENOTYPE": "wildtype", "COMPOUND": "acetaminophen (APAP)"}}, {"GSM929285": {"GENOTYPE": "wildtype", "COMPOUND": "acetaminophen (APAP)"}}, {"GSM929285": {"GENOTYPE": "wildtype", "COMPOUND": "acetaminophen (APAP)"}}, {"GSM929288": {"GENOTYPE": "txnrd1 null", "COMPOUND": "vehicle (saline)"}}, {"GSM929288": {"GENOTYPE": "txnrd1 null", "COMPOUND": "vehicle (saline)"}}, {"GSM929288": {"GENOTYPE": "txnrd1 null", "COMPOUND": "vehicle (saline)"}}, {"GSM92929": {"GENOTYPE": "txnrd1 null", "COMPOUND": "acetaminophen (APAP)"}}, {"GSM92929": {"GENOTYPE": "txnrd1 null", "COMPOUND": "acetaminophen (APAP)"}}, {"GSM92929": {"GENOTYPE": "txnrd1 null", "COMPOUND": "acetaminophen (APAP)"}}], "ownerprofile_id": "arrayexpress_sid", "platform": 8, "summary_wrapped": "Genetic disruption of thioredoxin reductase 1 protects against acetaminophen (APAP) toxicity. To determine the role of the thioredoxin...", "pubmed_id": 23743293, "geo_gse_id": "E-GEOD-37874", "owner_profile": "/profile/8773/arrayexpressuploader", "factor_count": 2, "sample_count": 12, "tags": ["liver"], "lastmodified": "Dec.12, 2014", "is_default": false, "geo_gds_id": "", "slug": "shifted-metabolic-bias-in-livers-of-mice-lacking-h", "geo_id_plat": "E-GEOD-37874_A-AFFY-36", "name": "Shifted Metabolic Bias in Livers of Mice Lacking Hepatocytic Thioredoxin Reductase-1 Protects Against Acetaminophen Toxicity", "created": "Nov.24, 2014", "summary": "Genetic disruption of thioredoxin reductase 1 protects against acetaminophen (APAP) toxicity. To determine the role of the thioredoxin system on xenobiotic metabolism we challeneged wildtype and txnrd1liver-null mice with acetaminophen. Adult male wildtype and txnrd1 liver-null mice (C57BL6/J) were treated with either saline (PBS) or 100mg/kg APAP. Liver RNA was harvested eight hours after challenge and processed for microarray analysis. Comparison of 2 treatment conditions in 2 genotypes, biological replicates in triplicate.", "source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-37874", "species": "mouse", "sample_source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-37874/samples/"}