ArrayExpress Uploader08624wildtypevehicle (saline)wildtypevehicle (saline)wildtypevehicle (saline)wildtypeacetaminophen (APAP)wildtypeacetaminophen (APAP)wildtypeacetaminophen (APAP)txnrd1 nullvehicle (saline)txnrd1 nullvehicle (saline)txnrd1 nullvehicle (saline)txnrd1 nullacetaminophen (APAP)txnrd1 nullacetaminophen (APAP)txnrd1 nullacetaminophen (APAP)arrayexpress_sid8Genetic disruption of thioredoxin reductase 1 protects against acetaminophen (APAP) toxicity. To determine the role of the thioredoxin...23743293E-GEOD-37874/profile/8773/arrayexpressuploader212liverDec.12, 2014Falseshifted-metabolic-bias-in-livers-of-mice-lacking-hE-GEOD-37874_A-AFFY-36Shifted Metabolic Bias in Livers of Mice Lacking Hepatocytic Thioredoxin Reductase-1 Protects Against Acetaminophen ToxicityNov.24, 2014Genetic disruption of thioredoxin reductase 1 protects against acetaminophen (APAP) toxicity. To determine the role of the thioredoxin system on xenobiotic metabolism we challeneged wildtype and txnrd1liver-null mice with acetaminophen. Adult male wildtype and txnrd1 liver-null mice (C57BL6/J) were treated with either saline (PBS) or 100mg/kg APAP. Liver RNA was harvested eight hours after challenge and processed for microarray analysis. Comparison of 2 treatment conditions in 2 genotypes, biological replicates in triplicate.http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-37874mousehttp://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-37874/samples/