Dataset: Shifted Metabolic Bias in Livers of Mice Lacking Hepatocytic Thioredoxin Reductase-1 Protects Against Acetaminophen Toxicity
Genetic disruption of thioredoxin reductase 1 protects against acetaminophen (APAP) toxicity. To determine the role of the thioredoxin...
Genetic disruption of thioredoxin reductase 1 protects against acetaminophen (APAP) toxicity. To determine the role of the thioredoxin system on xenobiotic metabolism we challeneged wildtype and txnrd1liver-null mice with acetaminophen. Adult male wildtype and txnrd1 liver-null mice (C57BL6/J) were treated with either saline (PBS) or 100mg/kg APAP. Liver RNA was harvested eight hours after challenge and processed for microarray analysis. Comparison of 2 treatment conditions in 2 genotypes, biological replicates in triplicate.
- Species:
- mouse
- Samples:
- 12
- Source:
- E-GEOD-37874
- PubMed:
- 23743293
- Updated:
- Dec.12, 2014
- Registered:
- Nov.24, 2014
Factors:
(via ArrayExpress)
| Sample | GENOTYPE | COMPOUND |
|---|---|---|
| GSM929282 | wildtype | vehicle (saline) |
| GSM929282 | wildtype | vehicle (saline) |
| GSM929282 | wildtype | vehicle (saline) |
| GSM929285 | wildtype | acetaminophen (APAP) |
| GSM929285 | wildtype | acetaminophen (APAP) |
| GSM929285 | wildtype | acetaminophen (APAP) |
| GSM929288 | txnrd1 null | vehicle (saline) |
| GSM929288 | txnrd1 null | vehicle (saline) |
| GSM929288 | txnrd1 null | vehicle (saline) |
| GSM92929 | txnrd1 null | acetaminophen (APAP) |
| GSM92929 | txnrd1 null | acetaminophen (APAP) |
| GSM92929 | txnrd1 null | acetaminophen (APAP) |