ArrayExpress Uploader06879nonewild typeVSV (1 M.O.I.) for 6 hrwild typeVSV (1 M.O.I.) for 6 hrIRF3-/-arrayexpress_sid6IRF3 is one of the most critical transcription factor in down stream of pattern recognition receptors (such as toll-like receptor and...22610141E-GEOD-37855/profile/8773/arrayexpressuploader23virus infectionDec.12, 2014Falsegene-expression-in-irf3-peritoneal-macrophage-infeE-GEOD-37855_A-AFFY-45Gene expression in IRF3-/- peritoneal macrophage infected with VSVNov.12, 2014IRF3 is one of the most critical transcription factor in down stream of pattern recognition receptors (such as toll-like receptor and RIG-I-like receptor) signalling pathway. IRF3 is known to induce the expression of type I IFN gene upon virus infection. To furter examine the role of IRF3 in virus-induced gene expression, we preformed microarray analysis in IRF3-/- peritoneal macrophages infected with VSV, and found that IRF3 suppresses the expression of Il12b gene. Peritoneal macrophages from WT of IRF3-/- B6 mice were infected with VSV(1 M.O.I. ) for 6 hous, and then subjected to microarray analysis.http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-37855mousehttp://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-37855/samples/