{"owner": "ArrayExpress Uploader", "pop_total": 0, "id": 6879, "factors": [{"GSM929070": {"TREATMENT": "none", "VARIATION": "wild type"}}, {"GSM92907": {"TREATMENT": "VSV (1 M.O.I.) for 6 hr", "VARIATION": "wild type"}}, {"GSM929072": {"TREATMENT": "VSV (1 M.O.I.) for 6 hr", "VARIATION": "IRF3-/-"}}], "ownerprofile_id": "arrayexpress_sid", "platform": 6, "summary_wrapped": "IRF3 is one of the most critical transcription factor in down stream of pattern recognition receptors (such as toll-like receptor and...", "pubmed_id": 22610141, "geo_gse_id": "E-GEOD-37855", "owner_profile": "/profile/8773/arrayexpressuploader", "factor_count": 2, "sample_count": 3, "tags": ["virus infection"], "lastmodified": "Dec.12, 2014", "is_default": false, "geo_gds_id": "", "slug": "gene-expression-in-irf3-peritoneal-macrophage-infe", "geo_id_plat": "E-GEOD-37855_A-AFFY-45", "name": "Gene expression in IRF3-/- peritoneal macrophage infected with VSV", "created": "Nov.12, 2014", "summary": "IRF3 is one of the most critical transcription factor in down stream of pattern recognition receptors (such as toll-like receptor and RIG-I-like receptor) signalling pathway. IRF3 is known to induce the expression of type I IFN gene upon virus infection. To furter examine the role of IRF3 in virus-induced gene expression, we preformed microarray analysis in IRF3-/- peritoneal macrophages infected with VSV, and found that IRF3 suppresses the expression of Il12b gene. Peritoneal macrophages from WT of IRF3-/- B6 mice were infected with VSV(1 M.O.I. ) for 6 hous, and then subjected to microarray analysis.", "source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-37855", "species": "mouse", "sample_source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-37855/samples/"}