Dataset: Gene expression in IRF3-/- peritoneal macrophage infected with VSV
IRF3 is one of the most critical transcription factor in down stream of pattern recognition receptors (such as toll-like receptor and...
IRF3 is one of the most critical transcription factor in down stream of pattern recognition receptors (such as toll-like receptor and RIG-I-like receptor) signalling pathway. IRF3 is known to induce the expression of type I IFN gene upon virus infection. To furter examine the role of IRF3 in virus-induced gene expression, we preformed microarray analysis in IRF3-/- peritoneal macrophages infected with VSV, and found that IRF3 suppresses the expression of Il12b gene. Peritoneal macrophages from WT of IRF3-/- B6 mice were infected with VSV(1 M.O.I. ) for 6 hous, and then subjected to microarray analysis.
- Species:
- mouse
- Samples:
- 3
- Source:
- E-GEOD-37855
- PubMed:
- 22610141
- Updated:
- Dec.12, 2014
- Registered:
- Nov.12, 2014
Factors:
(via ArrayExpress)
| Sample | TREATMENT | VARIATION |
|---|---|---|
| GSM929070 | none | wild type |
| GSM92907 | VSV (1 M.O.I.) for 6 hr | wild type |
| GSM929072 | VSV (1 M.O.I.) for 6 hr | IRF3-/- |