6ArrayExpress Uploaderarrayexpress_sidmousenoneB-DNA (10ug/ml) for 4 hrCpG-B(3uM) for 4 hr68780http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-37854Toll-like receptor and RIG-I-like receptor classs may evoke or instruct a distinct type of response that is more reflective of the...22610141/profile/8773/arrayexpressuploader13Dec.12, 2014Falsegene-expression-profile-in-peritoneal-macrophage-sE-GEOD-37854_A-AFFY-45Gene expression profile in peritoneal macrophage stimulated with B-DNA or CpG-BNov.12, 2014Toll-like receptor and RIG-I-like receptor classs may evoke or instruct a distinct type of response that is more reflective of the pathogen encountered. Although this issue may be critical to a better understanding of the regulation of immune responses to microbial infections, it has not been addressed through a direct, side-by-side comparison of the two receptor classes. To address this, we performed microarray analysis of mRNAs from peritoneal macrophages stimulated with a synthetic B-form DNA, poly(dA-dT)・poly(dT-dA) ( B-DNA) or a CpG-B oligonucleotide, which respectively activates RLRs or TLR9, and identified B-DNA inducible genes and CpG-B inducible genes. Peritoneal macrophages from B6 mice were stimulated with B-DNA (10μg/ml) or CpG-B(3μM) for 4 hous, and then subjected to microarray analysis.E-GEOD-37854http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-37854/samples/