{"owner": "ArrayExpress Uploader", "ownerprofile_id": "arrayexpress_sid", "species": "mouse", "factors": [{"GSM928993": {"DIET": "control casein (CAS) diet"}}, {"GSM928993": {"DIET": "control casein (CAS) diet"}}, {"GSM928995": {"DIET": "soy protein isolate (SPI) diet"}}, {"GSM928995": {"DIET": "soy protein isolate (SPI) diet"}}], "id": 6877, "pop_total": 0, "platform": 6, "summary_wrapped": "Maintenance and propagation of breast cancer stem cells (BCSCs) is mediated via cytokine and growth factor networks. Direct in vivo...", "geo_gse_id": "E-GEOD-37849", "owner_profile": "/profile/8773/arrayexpressuploader", "factor_count": 1, "sample_count": 4, "tags": ["basal", "breast", "breast cancer", "cancer", "cell", "cytokine", "protein", "stem cell"], "lastmodified": "Dec.12, 2014", "is_default": false, "geo_id_plat": "E-GEOD-37849_A-AFFY-45", "slug": "suppressed-cytokine-and-chemokine-transcriptional", "geo_gds_id": "", "name": "Suppressed cytokine and chemokine transcriptional signatures in mammary stem/progenitor cells are associated with dietary protection against Wnt1-driven mammary tumorigenesis", "created": "Nov.12, 2014", "summary": "Maintenance and propagation of breast cancer stem cells (BCSCs) is mediated via cytokine and growth factor networks. Direct in vivo linkage between dietary regulation of mammary stem (MaSC)/progenitor cell numbers and protection from breast cancer has not been reported. Here, we investigated the effect of post-weaning intake of soy protein isolate (SPI) relative to the control casein (CAS) diet on the stem/progenitor population and tumor formation in MMTV-Wnt1-Transgenic (Wnt1-Tg) female mice. Gene expression profile of the basal (MaSC-enriched) sub-population in preneoplastic Wnt1-Tg mice demonstrated a stem cell-like expression pattern and markedly suppressed expression of inflammatory cytokines, C-X-C family chemokines, and metastasis-associated genes with dietary SPI exposure. four Samples: two CAS diet, two SPI diet", "source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-37849", "sample_source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-37849/samples/"}