ArrayExpress Uploader0humannot specifiednot specifiednephrectomynot specifiednot specifiednot specifiednephrectomynephrectomynot specifiednot specifiedGSM880500not specifiednot specifiednephrectomynot specifiednot specifiednot specifiednephrectomynephrectomynot specifiednot specifiedGSM880447not specifiednot specifiednephrectomynot specifiednot specifiednot specifiednephrectomynephrectomynot specifiednot specifiedGSM880430not specifiednot specifiednephrectomynot specifiednot specifiednot specifiednephrectomynephrectomynot specifiednot specifiedGSM880318not specifiednot specifiednephrectomynot specifiednot specifiednot specifiednephrectomynephrectomynot specifiednot specifiedGSM880311not specifiednot specifiednephrectomynot specifiednot specifiednot specifiednephrectomynephrectomynot specifiednot specifiedGSM880299not specifiednot specifiednephrectomynot specifiednot specifiednot specifiednephrectomynephrectomynot specifiednot specifiedGSM880246not specifiednot specifiednephrectomynot specifiednot specifiednot specifiednephrectomynephrectomynot specifiednot specifiedGSM88024533.330.382renal allograft biopsy290.999IGFgood213not specified3.030.804renal allograft biopsy0161.281IGFgood055not specified18.181.135renal allograft biopsynot specified412.032IGFbadnot specified68not specifiednot specified1.066renal allograft biopsy4431.528DGFbad452not specified2.560.495renal allograft biopsy0160.779IGFgood017not specifiednot specified0.745renal allograft biopsynot specified231.116IGFgoodnot specified39not specified8.330.451renal allograft biopsy4110.85IGFgood426not specified3.030.765renal allograft biopsy0221.267IGFgood055not specified01.009renal allograft biopsy4191.187IGFgood453not specified00.678renal allograft biopsy760.97IGFgood719not specified00.644renal allograft biopsy7130.681IGFgood718not specifiednot specified0.922renal allograft biopsynot specified401.668DGFbadnot specified50not specified4.350.873renal allograft biopsy3221.362DGFbad352not specified00.426renal allograft biopsynot specified80.756IGFgoodnot specified17not specified16.670.941renal allograft biopsy2221.546DGFbad263not specified00.57renal allograft biopsy470.952IGFgood422not specified00.881renal allograft biopsy381.143IGFbad339not specified501.127renal allograft biopsynot specified361.639IGFgoodnot specified65not specified00.495renal allograft biopsy0120.818IGFgood016not specified00.678renal allograft biopsy4140.93IGFgood425not specifiednot specified0.901renal allograft biopsy4211.426IGFgood454not specified00.804renal allograft biopsy7192.174IGFgood74not specified00.737renal allograft biopsy3291.176DGFbad354not specified40.803renal allograft biopsy4151.191IGFgood452not specified3.081.022renal allograft biopsy0111.291IGFgood053not specified251.011renal allograft biopsy6251.543IGFgood658not specified00.786renal allograft biopsy0271.302IGFgood043not specified6.41.307renal allograft biopsy7311.743IGFgood769not specified00.873renal allograft biopsy4311.562IGFgood459not specified00.791renal allograft biopsy4361.392IGFgood434not specified6.41.354renal allograft biopsy4362.108IGFgood469not specified12.50.583renal allograft biopsy7461.16IGFgood748not specified00.85renal allograft biopsy4201.311IGFgood442not specified250.873renal allograft biopsy9342.675IGFgood950not specified00.589renal allograft biopsy0111.002IGFgood028not specified11.110.747renal allograft biopsy0231.147IGFgood033not specified161.221renal allograft biopsy6353.991DGFbad670not specified00.382renal allograft biopsy491.037DGFbad413not specified00.426renal allograft biopsy0180.79IGFgood019not specified00.804renal allograft biopsy4111.14IGFgood453not specifiednot specified0.917renal allograft biopsynot specified211.464IGFgoodnot specified59not specified3.330.786renal allograft biopsy0221.097IGFgood043not specified00.855renal allograft biopsy0170.981DGFbad043not specified16.670.431renal allograft biopsy2151.007IGFgood246not specified00.722renal allograft biopsynot specified220.755IGFgoodnot specified18not specifiednot specified1.086renal allograft biopsy0211.752DGFbad066not specified00.722renal allograft biopsy4171IGFgood419not specified12.50.765renal allograft biopsynot specified211.164IGFgoodnot specified54not specified00.719renal allograft biopsy0161.191IGFgood043not specified27.270.631renal allograft biopsy6180.812IGFgood623not specified01.127renal allograft biopsy4141.594DGFbad465not specified8.330.687renal allograft biopsy0280.998DGFbad052not specified15.790.946renal allograft biopsy6141.243IGFgood643not specified00.855renal allograft biopsy0131.111IGFbad047not specified11.110.719renal allograft biopsy3391.167IGFgood343not specified18.180.92renal allograft biopsynot specified391.442IGFgoodnot specified52not specified7.140.533renal allograft biopsy4180.968IGFgood446not specified00.94renal allograft biopsy3111.194IGFbad351not specified01.1renal allograft biopsy0181.497IGFgood056not specified14.290.806renal allograft biopsy0251.265IGFgood055not specified17.741.236renal allograft biopsy6291.711IGFgood652not specified00.587renal allograft biopsy080.765IGFgood017not specified9.090.694renal allograft biopsy4141.342IGFgood443not specified00.384renal allograft biopsy390.679IGFgood317not specified00.495renal allograft biopsy4110.867IGFgood416not specified00.451renal allograft biopsy3130.758IGFgood323not specified00.6renal allograft biopsy0110.84IGFgood022not specified01.144renal allograft biopsynot specified301.524DGFbadnot specified51not specified01.144renal allograft biopsynot specified331.516IGFbadnot specified53not specifiednot specified0.806renal allograft biopsynot specified191.351IGFgoodnot specified59not specified2542arrayexpress_sid4In deceased donor kidney transplantation, acute kidney injury (AKI) prioir to surgery is a major determinant of delayed graft function...E-GEOD-37838/profile/8773/arrayexpressuploader1178glomerulosclerosiskidneyserumDec.12, 2014Falsecomparing-three-phenotypes-comparing-molecular-assE-GEOD-37838_A-AFFY-44Comparing three phenotypes: Comparing molecular assessment of implantation biopsyJul.12, 2014In deceased donor kidney transplantation, acute kidney injury (AKI) prioir to surgery is a major determinant of delayed graft function (DGF), but AKI is histologically silent and difficult to assess. We hypothesized that a molecular measurement of AKI would add power to conventional risk assessments to predict the early poor allograft function at first week post transplantation. We performed microarrays on implantation biopsies taken during reperfusion in 70 deceased donor kidneys from 53 donors. Early poor function was classified by two definitions on day 7 post-transplantation: serum creatinine greater than 265 umol/L (3 mg/dL) or the requirement for dialysis. Donor age and related risk scores (Irish, Schold, KDRI) associated with worse early function, as expected, but histologic features (glomerulosclerosis; pathology risk scores (Remuzzi, MAPI)) correlated with donor age but not with poor function. However, molecular AKI signal, previously defined in kidneys with early injury, was the best single predictor of poor allograft function. The combination of donor age and the AKI signal improved the prediction of poor function. In addition, asssessments of tissue quality particularly donor age, Banff ct, Irish and KDRI scores, showed negative correlative trend with late graft function, whereas the AKI signal did not. Thus donor age and the molecular AKI signal are the main predictors of early impaired function, but have little impact on survival.http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-37838http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-37838/samples/