6ArrayExpress Uploaderarrayexpress_sidmouseEμ-Myc + ;Eµ-TTP-1 -Eμ-Myc + ;Eµ-TTP-1 -Eμ-Myc + ;Eµ-TTP-1 -Eμ-Myc + ;Eµ-TTP-1 -Eμ-Myc + ;Eµ-TTP-1 +Eμ-Myc + ;Eµ-TTP-1 +Eμ-Myc + ;Eµ-TTP-1 +Eμ-Myc + ;Eµ-TTP-1 +Eμ-Myc + ;Eµ-TTP-1 +68740http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-37790Myc oncoproteins directly regulate transcription by binding to target genes, yet this only explains a fraction of the genes affected by...22863009/profile/8773/arrayexpressuploader19cancerDec.12, 2014Falsetristetraprolin-is-a-tumor-suppressor-that-impai-2E-GEOD-37790_A-AFFY-45Tristetraprolin is a tumor suppressor that impairs Myc-induced lymphoma and abolishes the malignant state [Lymphoma].Nov.12, 2014Myc oncoproteins directly regulate transcription by binding to target genes, yet this only explains a fraction of the genes affected by Myc. mRNA turnover is controlled via AU-binding proteins (AUBPs) that recognize AU-rich elements (AREs) found within many transcripts. Analyses of precancerous and malignant Myc-expressing B cells revealed that Myc regulates hundreds of ARE-containing (ARED) genes and select AUBPs. Notably, Myc directly suppresses transcription of Tristetraprolin (TTP/ZFP36), an mRNA-destabilizing AUBP, and this circuit is also operational during B lymphopoiesis and IL7 signaling. Importantly, TTP suppression is a hallmark of cancers with MYC involvement, and restoring TTP impairs Myc-induced lymphomagenesis and abolishes maintenance of the malignant state. Further, there is a selection for TTP loss in malignancy; thus, TTP functions as a tumor suppressor. Finally, Myc/TTP-directed control of select cancer-associated ARED genes is disabled during lymphomagenesis. Thus, Myc targets AUBPs to regulate ARED genes that control tumorigenesis. Lymphomas collected from Eμ-Myc and Eμ-Myc;Eµ-TTP-1 transgenic mice were investigated. These samples were used for subsequent RNA purification, labeling and hybridization to MOE430 2.0 Affymetrix arrays.E-GEOD-37790http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-37790/samples/