{"owner": "ArrayExpress Uploader", "ownerprofile_id": "arrayexpress_sid", "species": "mouse", "factors": [{"GSM915950": {"VARIATION": "not specified", "ORGANISM PART": "cerebellar white matter", "CELL TYPE": "neural stem cells (NSCs)"}}, {"GSM915950": {"VARIATION": "not specified", "ORGANISM PART": "cerebellar white matter", "CELL TYPE": "neural stem cells (NSCs)"}}, {"GSM915950": {"VARIATION": "not specified", "ORGANISM PART": "cerebellar white matter", "CELL TYPE": "neural stem cells (NSCs)"}}, {"GSM915953": {"VARIATION": "not specified", "ORGANISM PART": "IV ventricle region", "CELL TYPE": "neural stem cells (NSCs)"}}, {"GSM915953": {"VARIATION": "not specified", "ORGANISM PART": "IV ventricle region", "CELL TYPE": "neural stem cells (NSCs)"}}, {"GSM915953": {"VARIATION": "not specified", "ORGANISM PART": "IV ventricle region", "CELL TYPE": "neural stem cells (NSCs)"}}, {"GSM915956": {"VARIATION": "Ptch het p53 het", "ORGANISM PART": "medulloblastoma", "CELL TYPE": "cancer stem cells (CSCs)"}}, {"GSM915956": {"VARIATION": "Ptch het p53 het", "ORGANISM PART": "medulloblastoma", "CELL TYPE": "cancer stem cells (CSCs)"}}, {"GSM915956": {"VARIATION": "Ptch het p53 het", "ORGANISM PART": "medulloblastoma", "CELL TYPE": "cancer stem cells (CSCs)"}}, {"GSM915959": {"VARIATION": "Ptch het p53 wt", "ORGANISM PART": "medulloblastoma", "CELL TYPE": "cancer stem cells (CSCs)"}}, {"GSM915960": {"VARIATION": "Ptch het p53 wt", "ORGANISM PART": "medulloblastoma", "CELL TYPE": "not specified"}}, {"GSM915959": {"VARIATION": "Ptch het p53 wt", "ORGANISM PART": "medulloblastoma", "CELL TYPE": "cancer stem cells (CSCs)"}}, {"GSM915960": {"VARIATION": "Ptch het p53 wt", "ORGANISM PART": "medulloblastoma", "CELL TYPE": "not specified"}}, {"GSM915959": {"VARIATION": "Ptch het p53 wt", "ORGANISM PART": "medulloblastoma", "CELL TYPE": "cancer stem cells (CSCs)"}}, {"GSM915960": {"VARIATION": "Ptch het p53 wt", "ORGANISM PART": "medulloblastoma", "CELL TYPE": "not specified"}}, {"GSM915959": {"VARIATION": "Ptch het p53 wt", "ORGANISM PART": "medulloblastoma", "CELL TYPE": "cancer stem cells (CSCs)"}}, {"GSM915960": {"VARIATION": "Ptch het p53 wt", "ORGANISM PART": "medulloblastoma", "CELL TYPE": "not specified"}}, {"GSM915956": {"VARIATION": "Ptch het p53 het", "ORGANISM PART": "medulloblastoma", "CELL TYPE": "cancer stem cells (CSCs)"}}, {"GSM915956": {"VARIATION": "Ptch het p53 het", "ORGANISM PART": "medulloblastoma", "CELL TYPE": "cancer stem cells (CSCs)"}}, {"GSM915956": {"VARIATION": "Ptch het p53 het", "ORGANISM PART": "medulloblastoma", "CELL TYPE": "cancer stem cells (CSCs)"}}, {"GSM915959": {"VARIATION": "Ptch het p53 wt", "ORGANISM PART": "medulloblastoma", "CELL TYPE": "cancer stem cells (CSCs)"}}, {"GSM915960": {"VARIATION": "Ptch het p53 wt", "ORGANISM PART": "medulloblastoma", "CELL TYPE": "not specified"}}, {"GSM915959": {"VARIATION": "Ptch het p53 wt", "ORGANISM PART": "medulloblastoma", "CELL TYPE": "cancer stem cells (CSCs)"}}, {"GSM915960": {"VARIATION": "Ptch het p53 wt", "ORGANISM PART": "medulloblastoma", "CELL TYPE": "not specified"}}, {"GSM915959": {"VARIATION": "Ptch het p53 wt", "ORGANISM PART": "medulloblastoma", "CELL TYPE": "cancer stem cells (CSCs)"}}, {"GSM915960": {"VARIATION": "Ptch het p53 wt", "ORGANISM PART": "medulloblastoma", "CELL TYPE": "not specified"}}, {"GSM915959": {"VARIATION": "Ptch het p53 wt", "ORGANISM PART": "medulloblastoma", "CELL TYPE": "cancer stem cells (CSCs)"}}, {"GSM915960": {"VARIATION": "Ptch het p53 wt", "ORGANISM PART": "medulloblastoma", "CELL TYPE": "not specified"}}, {"GSM915978": {"VARIATION": "not specified", "ORGANISM PART": "subventricular zone", "CELL TYPE": "neural stem cells (NSCs)"}}, {"GSM915978": {"VARIATION": "not specified", "ORGANISM PART": "subventricular zone", "CELL TYPE": "neural stem cells (NSCs)"}}, {"GSM915978": {"VARIATION": "not specified", "ORGANISM PART": "subventricular zone", "CELL TYPE": "neural stem cells (NSCs)"}}], "id": 6853, "pop_total": 0, "platform": 6, "summary_wrapped": "We exploited microarrays to detail the global program of gene expression underlying normal stem cells and cancer stem cells in the...", "owner_profile": "/profile/8773/arrayexpressuploader", "factor_count": 3, "sample_count": 31, "tags": ["cancer", "cerebellum", "hindbrain"], "lastmodified": "Dec.12, 2014", "is_default": false, "geo_id_plat": "E-GEOD-37316_A-AFFY-45", "slug": "gene-expression-data-from-postnatal-day-7-subventr", "source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-37316", "geo_gds_id": "", "name": "Gene expression data from postnatal day 7 subventricular zone (SVZ), IV ventricle and cerebellar white matter-derived neural stem cells (NSCs) and of cancer stem cells (CSCs) from Ptch het p53 wt and Ptch het p53 het mouse medulloblastomas", "created": "Nov.12, 2014", "summary": "We exploited microarrays to detail the global program of gene expression underlying normal stem cells and cancer stem cells in the cerebellum and in medulloblastomas (MBs). To identify novel molecular mediators involved in medulloblastomagenesis, we compared the distinct postnatal hindbrain-derived NSC populations, which are potentially tumor-initiating, with murine single Ptch and compound Ptch/p53-mutant MB cancer stem cells (CSCs), the latter faithfully phenocopying the different variants of human MB in vivo. Transcriptome analysis of both hindbrain NSCs and MB CSCs resulted in the generation of well-defined gene signatures, each reminiscent of a specific human MB molecular subclass.", "geo_gse_id": "E-GEOD-37316", "sample_source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-37316/samples/"}