ArrayExpress Uploader0humanbreast adenocarcinoma (derived from metastatic site: pleural effusion)control two-dimensional cultures (2DC)TNBC cell line MDA-MB-231breast adenocarcinoma (derived from metastatic site: pleural effusion)3D cultures (3DC)TNBC cell line MDA-MB-231breast adenocarcinoma (derived from metastatic site: pleural effusion)tumor xenograft modelTNBC cell line MDA-MB-231breast carcinomacontrol two-dimensional cultures (2DC)TNBC cell line Hs578Tbreast carcinoma3D cultures (3DC)TNBC cell line Hs578Tbreast carcinomatumor xenograft modelTNBC cell line Hs578T4457arrayexpress_sid4Triple-negative breast cancer (TNBC) is defined by the absence of estrogen and progesterone receptors and human epidermal growth factor...E-GEOD-36953/profile/8773/arrayexpressuploader36breastbreast cancercancerestrogengenomeDec.12, 2014Falsegene-expression-profiles-of-triple-negative-breastE-GEOD-36953_A-AFFY-44Gene expression profiles of triple-negative breast cancer cells under the condition of 3D proliferationSep.19, 2014Triple-negative breast cancer (TNBC) is defined by the absence of estrogen and progesterone receptors and human epidermal growth factor receptor 2, and is the most lethal and aggressive subtype of breast cancer. However, the genes which relate to promote tumor aggressiveness in TNBC remain unclear. In order to investigate specific genes and pathways involved in TNBC tumorigenesis, we compared genes differentially expressed between 3D cultures (3DC) or tumor xenograft models and control two-dimensional cultures (2DC). Total RNA was prepared from the TNBC cells under the condition of 2DC, 3DC and tumor xenograft models, and applied to Affymetrix Human Genome U133 Plus 2.0 Array.http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-36953http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-36953/samples/