{"owner": "ArrayExpress Uploader", "pop_total": 0, "species": "human", "factors": [{"GSM907019": {"DISEASE STATE": "breast adenocarcinoma (derived from metastatic site: pleural effusion)", "GROWTH CONDITION": "control two-dimensional cultures (2DC)", "CELL LINE": "TNBC cell line MDA-MB-231"}}, {"GSM907020": {"DISEASE STATE": "breast adenocarcinoma (derived from metastatic site: pleural effusion)", "GROWTH CONDITION": "3D cultures (3DC)", "CELL LINE": "TNBC cell line MDA-MB-231"}}, {"GSM90702": {"DISEASE STATE": "breast adenocarcinoma (derived from metastatic site: pleural effusion)", "GROWTH CONDITION": "tumor xenograft model", "CELL LINE": "TNBC cell line MDA-MB-231"}}, {"GSM907022": {"DISEASE STATE": "breast carcinoma", "GROWTH CONDITION": "control two-dimensional cultures (2DC)", "CELL LINE": "TNBC cell line Hs578T"}}, {"GSM907023": {"DISEASE STATE": "breast carcinoma", "GROWTH CONDITION": "3D cultures (3DC)", "CELL LINE": "TNBC cell line Hs578T"}}, {"GSM907024": {"DISEASE STATE": "breast carcinoma", "GROWTH CONDITION": "tumor xenograft model", "CELL LINE": "TNBC cell line Hs578T"}}], "id": 4457, "ownerprofile_id": "arrayexpress_sid", "platform": 4, "summary_wrapped": "Triple-negative breast cancer (TNBC) is defined by the absence of estrogen and progesterone receptors and human epidermal growth factor...", "geo_gse_id": "E-GEOD-36953", "owner_profile": "/profile/8773/arrayexpressuploader", "factor_count": 3, "sample_count": 6, "tags": ["breast", "breast cancer", "cancer", "estrogen", "genome"], "lastmodified": "Dec.12, 2014", "is_default": false, "geo_gds_id": "", "slug": "gene-expression-profiles-of-triple-negative-breast", "geo_id_plat": "E-GEOD-36953_A-AFFY-44", "name": "Gene expression profiles of triple-negative breast cancer cells under the condition of 3D proliferation", "created": "Sep.19, 2014", "summary": "Triple-negative breast cancer (TNBC) is defined by the absence of estrogen and progesterone receptors and human epidermal growth factor receptor 2, and is the most lethal and aggressive subtype of breast cancer. However, the genes which relate to promote tumor aggressiveness in TNBC remain unclear. In order to investigate specific genes and pathways involved in TNBC tumorigenesis, we compared genes differentially expressed between 3D cultures (3DC) or tumor xenograft models and control two-dimensional cultures (2DC). Total RNA was prepared from the TNBC cells under the condition of 2DC, 3DC and tumor xenograft models, and applied to Affymetrix Human Genome U133 Plus 2.0 Array.", "source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-36953", "sample_source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-36953/samples/"}