{"owner": "ArrayExpress Uploader", "pop_total": 0, "species": "mouse", "factors": [{"GSM901088": {"AGE": "4 months"}}, {"GSM901089": {"AGE": "8 months"}}, {"GSM901090": {"AGE": "13 months"}}, {"GSM90109": {"AGE": "21 months"}}], "id": 6832, "ownerprofile_id": "arrayexpress_sid", "platform": 6, "summary_wrapped": "Dietary interventions are effective ways to extend or shorten lifespan. By examining midlife hepatic gene expressions in mice under...", "geo_gse_id": "E-GEOD-36836", "owner_profile": "/profile/8773/arrayexpressuploader", "factor_count": 1, "sample_count": 4, "tags": ["liver", "point"], "lastmodified": "Dec.12, 2014", "is_default": false, "geo_gds_id": "", "slug": "expression-profiling-of-aging-liver-in-low-fat-die", "geo_id_plat": "E-GEOD-36836_A-AFFY-45", "name": "Expression profiling of aging liver in low-fat diet mice", "created": "Nov.12, 2014", "summary": "Dietary interventions are effective ways to extend or shorten lifespan. By examining midlife hepatic gene expressions in mice under different dietary conditions, which resulted in different lifespans and aging-related phenotypes, we were able to identify genes and pathways that modulate the aging process. To determine how our dietary intervention-based transcriptomic approach for predicting aging-regulatory genes compares to more traditional approach of using age-dependent transcriptional changes, we examined the hepatic gene expression changes in LF-fed mice during aging at 4, 8, 13 and 21 months. Male C57BL/6J mice at 4 weeks of age were purchased from Shanghai Animal Co, Ltd. Mice were maintained under a 12-hour dark/light cycle (lights on at 6:30 am) at a temperature of 22 \u00b1 3 \u00b0C in accredited animal facilities. Prior to the start of experiment, mice were maintained on a low-fat diet (Research Diets Inc., New Brunswick, NJ) for one week. Liver RNAs extracted from six male C57BL/6J mice of the same age were pooled at each age point to obtain an average microarray profile at 4, 8, 13 and 21 months.", "source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-36836", "sample_source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-36836/samples/"}