ArrayExpress Uploader0mouseTransgenic mouse, human ATZ hepatocyte expressionmaleTransgenic mouse, human ATZ hepatocyte expressionfemalewild typemalewild typefemale8281arrayexpress_sid7Individuals expressing alpha-1-antitrypsin mutant Z protein accumulate misfolded, mutant protein in the liver and are at risk for liver...E-GEOD-36478/profile/8773/arrayexpressuploader24carcinomacirrhosisdiseasehepatocellular carcinomaliverliver diseaseproteinDec.12, 2014FalseE-GEOD-36478_A-AFFY-23gene-expression-levels-in-piz-mice-compared-to-wilGene Expression Levels in PiZ mice Compared to Wild-type (Wt)C57Bl/6Nov.23, 2014Individuals expressing alpha-1-antitrypsin mutant Z protein accumulate misfolded, mutant protein in the liver and are at risk for liver diseases including cirrhosis and hepatocellular carcinoma. Transgenic PiZ mice, a model for this liver disease, display similar pathologies to humans, including inflammation, increases in proliferation, autophagy and apoptosis, accumulation of globules and develop fibrosis and hepatocellular carcinoma with age. Microarrays were used to compare the gene expressions of PiZ mice to wild-type mice in order to identify the pathways that are altered in this disorder. Pooled samples from 4 mice, 3-4 months old were used for each of 4 categories. PiZ males, PiZ females, C57Bl/6 males, C57Bl/6 femaleshttp://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-36478http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-36478/samples/