ArrayExpress Uploader0mouse0.02457.599.19Aorta banding17.19no heart failure0.15790.13040.02456.4210.83Aorta banding17.34no heart failure0.18780.11140.02797.219.03Aorta banding17.88no heart failure0.16140.1290.02117.138.71Aorta banding17.4no heart failure0.15160.1240.02366.478.82Aorta banding17.47no heart failure0.15410.11310.02187.278.52Aorta banding17.75no heart failure0.15130.12910.01976.788.58Aorta banding17.51no heart failure0.15020.11870.0419.7520.9Aorta banding17.86heart failure0.37320.17410.03598.6917.92Aorta banding17.72heart failure0.31750.1540.0399.3924.62Aorta banding18.25heart failure0.44940.17140.02958.0919.28Aorta banding17.48heart failure0.3370.14150.03968.6620.48Aorta banding17.4heart failure0.35640.15060.02968.6318.76Aorta banding17.06heart failure0.320.14720.03749.5821.1Aorta banding17.21heart failure0.36320.16480.02665.348.75SHAM17.75SHAM0.15530.09470.02364.828.27SHAM17.64SHAM0.14580.0850.02945.038.33SHAM17.92SHAM0.14920.09010.02215.479.38SHAM17.96SHAM0.16840.09830.02185.068.2SHAM17.52SHAM0.14370.08866798arrayexpress_sid6The aim of the present study was to examine potential differences in the regulation of myocardial ECM constituents, in mice that develop...E-GEOD-36074/profile/8773/arrayexpressuploader819aortaascending aortaheartleftlungtibiaDec.12, 2014Falsedifferential-regulation-of-extracellular-matrix-coE-GEOD-36074_A-AFFY-45Differential regulation of extracellular matrix constituents in compensated versus decompensated heart failure following pressure overloadNov.12, 2014The aim of the present study was to examine potential differences in the regulation of myocardial ECM constituents, in mice that develop hypertrophy only (ABnonHF) and in mice that develop overt heart failure (ABHF) as response to pressure overload. Seven weeks old male C57BL/6 mice were subjected to aortic banding (AB) or sham operation (sAB), with sacrifice 4 weeks after banding. Prior to sacrifice, cardiac function and geometry were evaluated by echocardiography. Animals with comparable gradients over the banded ascending aorta, comparable cardiac output and heart rate were divided into two groups: ABnonHF and ABHF. Our criterion for dividing AB animals into these two groups was based on lung weight and left atrial diameter (LAD), as an increase in these parameters most likely is due to pulmonary congestion. Heart failure (HF) was defined as an increase in lung weight and LAD defining ABnonHF as lung weight/tibia length ≤ 10.5 mg/mm and LAD ≤ 2.0 mm and ABHF as lung weight/tibia length ≥ 15 mg/mm and LAD ≥ 2.4 mm. Microarray screening was performed in 7 mice from each AB group and in 5 sAB mice. Sham was used as control.http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-36074http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-36074/samples/