ArrayExpress Uploader0humandonor 1 (MSC population #520)female79 yrs (elderly-aged)passage 1donor 2 (MSC population #559)male79 yrs (elderly-aged)passage 1donor 3 (MSC population #606)female80 yrs (elderly-aged)passage 1donor 4 (MSC population #663)female89 yrs (elderly-aged)passage 1donor 1 with primary osteoporosis (MSC population #535)female79 yrs (elderly)passage 1donor 2 with primary osteoporosis (MSC population #547)female94 yrs (elderly)passage 1donor 3 with primary osteoporosis (MSC population #558)female87 yrs (elderly)passage 2donor 4 with primary osteoporosis (MSC population #572)female82 yrs (elderly)passage 1donor 5 with primary osteoporosis (MSC population #573)female89 yrs (elderly)passage 14426arrayexpress_sid4In the present study we analyzed the effect of primary osteoporosis on the transcriptome of human mesenchymal stem cells (hMSC;...E-GEOD-35958/profile/8773/arrayexpressuploader49bonebone marrowhipneckosteoarthritisosteoporosisDec.12, 2014Falseeffects-of-primary-osteoporosis-on-human-mesenchymE-GEOD-35958_A-AFFY-44Effects of Primary Osteoporosis on Human Mesenchymal Stem CellsSep.19, 2014In the present study we analyzed the effect of primary osteoporosis on the transcriptome of human mesenchymal stem cells (hMSC; alternatively named mesenchymal stromal cells) from human bone marrow. Human MSC of elderly patients suffering from osteoporosis were isolated from femoral heads after low-energy fracture of the femoral neck. Bone marrow of age-matched, non-osteoporotic donors was obtained of femoral heads after total hip arthroplasty. Cells were isolated from human bone marrow according to the previously described protocol (Noth et al., 2002, J Orthop Res, 20/5, 1060-1069) under agreement of the local Ethics Committee of the University of Würzburg. Human MSC of elderly patients suffering from osteoporosis were isolated from femoral heads after low-energy fracture of the femoral neck. Additional criteria for confirming primary osteoporosis in these donors were vertebrae fractures and advanced age. Bone marrow of age-matched, non-osteoporotic donors was obtained of femoral heads after total hip arthroplasty due to osteoarthritis and/or hip dysplasia. RNA samples were taken from passage 1 or passage 2.http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-35958http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-35958/samples/