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Home › Dataset Library › Effects of Primary Osteoporosis on Human Mesenchymal Stem Cells

Dataset: Effects of Primary Osteoporosis on Human Mesenchymal Stem Cells

In the present study we analyzed the effect of primary osteoporosis on the transcriptome of human mesenchymal stem cells (hMSC;...

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In the present study we analyzed the effect of primary osteoporosis on the transcriptome of human mesenchymal stem cells (hMSC; alternatively named mesenchymal stromal cells) from human bone marrow. Human MSC of elderly patients suffering from osteoporosis were isolated from femoral heads after low-energy fracture of the femoral neck. Bone marrow of age-matched, non-osteoporotic donors was obtained of femoral heads after total hip arthroplasty. Cells were isolated from human bone marrow according to the previously described protocol (Noth et al., 2002, J Orthop Res, 20/5, 1060-1069) under agreement of the local Ethics Committee of the University of Würzburg. Human MSC of elderly patients suffering from osteoporosis were isolated from femoral heads after low-energy fracture of the femoral neck. Additional criteria for confirming primary osteoporosis in these donors were vertebrae fractures and advanced age. Bone marrow of age-matched, non-osteoporotic donors was obtained of femoral heads after total hip arthroplasty due to osteoarthritis and/or hip dysplasia. RNA samples were taken from passage 1 or passage 2.

Species:
human

Samples:
9

Source:
E-GEOD-35958

Updated:
Dec.12, 2014

Registered:
Sep.19, 2014


Factors: (via ArrayExpress)
Sample SAMPLE ID GENDER AGE PASSAGE
GSM878100 donor 1 (MSC population #520) female 79 yrs (elderly-aged) passage 1
GSM87810 donor 2 (MSC population #559) male 79 yrs (elderly-aged) passage 1
GSM878102 donor 3 (MSC population #606) female 80 yrs (elderly-aged) passage 1
GSM878103 donor 4 (MSC population #663) female 89 yrs (elderly-aged) passage 1
GSM878104 donor 1 with primary osteoporosis (MSC population #535) female 79 yrs (elderly) passage 1
GSM878105 donor 2 with primary osteoporosis (MSC population #547) female 94 yrs (elderly) passage 1
GSM878106 donor 3 with primary osteoporosis (MSC population #558) female 87 yrs (elderly) passage 2
GSM878107 donor 4 with primary osteoporosis (MSC population #572) female 82 yrs (elderly) passage 1
GSM878108 donor 5 with primary osteoporosis (MSC population #573) female 89 yrs (elderly) passage 1

Tags

  • bone
  • bone marrow
  • hip
  • neck
  • osteoarthritis
  • osteoporosis

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