Dataset: Effects of Primary Osteoporosis on Human Mesenchymal Stem Cells
In the present study we analyzed the effect of primary osteoporosis on the transcriptome of human mesenchymal stem cells (hMSC;...
In the present study we analyzed the effect of primary osteoporosis on the transcriptome of human mesenchymal stem cells (hMSC; alternatively named mesenchymal stromal cells) from human bone marrow. Human MSC of elderly patients suffering from osteoporosis were isolated from femoral heads after low-energy fracture of the femoral neck. Bone marrow of age-matched, non-osteoporotic donors was obtained of femoral heads after total hip arthroplasty. Cells were isolated from human bone marrow according to the previously described protocol (Noth et al., 2002, J Orthop Res, 20/5, 1060-1069) under agreement of the local Ethics Committee of the University of Würzburg. Human MSC of elderly patients suffering from osteoporosis were isolated from femoral heads after low-energy fracture of the femoral neck. Additional criteria for confirming primary osteoporosis in these donors were vertebrae fractures and advanced age. Bone marrow of age-matched, non-osteoporotic donors was obtained of femoral heads after total hip arthroplasty due to osteoarthritis and/or hip dysplasia. RNA samples were taken from passage 1 or passage 2.
- Species:
- human
- Samples:
- 9
- Source:
- E-GEOD-35958
- Updated:
- Dec.12, 2014
- Registered:
- Sep.19, 2014
Sample | SAMPLE ID | GENDER | AGE | PASSAGE |
---|---|---|---|---|
GSM878100 | donor 1 (MSC population #520) | female | 79 yrs (elderly-aged) | passage 1 |
GSM87810 | donor 2 (MSC population #559) | male | 79 yrs (elderly-aged) | passage 1 |
GSM878102 | donor 3 (MSC population #606) | female | 80 yrs (elderly-aged) | passage 1 |
GSM878103 | donor 4 (MSC population #663) | female | 89 yrs (elderly-aged) | passage 1 |
GSM878104 | donor 1 with primary osteoporosis (MSC population #535) | female | 79 yrs (elderly) | passage 1 |
GSM878105 | donor 2 with primary osteoporosis (MSC population #547) | female | 94 yrs (elderly) | passage 1 |
GSM878106 | donor 3 with primary osteoporosis (MSC population #558) | female | 87 yrs (elderly) | passage 2 |
GSM878107 | donor 4 with primary osteoporosis (MSC population #572) | female | 82 yrs (elderly) | passage 1 |
GSM878108 | donor 5 with primary osteoporosis (MSC population #573) | female | 89 yrs (elderly) | passage 1 |