Dataset: Transcriptional Signatures as a Disease-Specific and Predictive Inflammatory Biomarker for Type 1 Diabetes [Pneu_S3S24_10Pneu_4HC]
The complex milieu of inflammatory mediators associated with many diseases is often too dilute to directly measure in the periphery,...
The complex milieu of inflammatory mediators associated with many diseases is often too dilute to directly measure in the periphery, necessitating development of more sensitive measurements suitable for mechanistic studies, earlier diagnosis, guiding selection of therapy, and monitoring interventions. Previously, we determined that plasma of recent-onset (RO) Type 1 diabetes (T1D) patients induce a proinflammatory transcriptional signature in fresh peripheral blood mononuclear cells (PBMC) relative to that of unrelated healthy controls (HC). Here, using an optimized cryopreserved PBMC-based protocol, we compared the signature found between unrelated healthy controls and patients with bacterial pneumonia. UPN727 cells were stimulated with either plasma from unrelated healthy controls (n=18) or plasma from patients with bacterial pneumonia (n=10). Gene expression analysis was perfromed in order to evaluate the transcriptional signature associated with bacterial pneumonia.
- Species:
- human
- Samples:
- 28
- Source:
- E-GEOD-35716
- Updated:
- Dec.12, 2014
- Registered:
- Sep.19, 2014
| Sample | PROTOCOL |
|---|---|
| GSM873833 | stimuated with HC1259 plasma |
| GSM873834 | stimuated with HC1369 plasma |
| GSM873835 | stimuated with HC381 plasma |
| GSM873836 | stimuated with HC389 plasma |
| GSM873837 | stimuated with HC1534 plasma |
| GSM873838 | stimuated with HC1730 plasma |
| GSM873839 | stimuated with HC217 plasma |
| GSM873840 | stimuated with HC226 plasma |
| GSM87384 | stimuated with HC2301 plasma |
| GSM873842 | stimuated with HC294 plasma |
| GSM873843 | stimuated with HC295 plasma |
| GSM873844 | stimuated with HC385 plasma |
| GSM873845 | stimuated with HC390 plasma |
| GSM873846 | stimuated with HC393 plasma |
| GSM873847 | stimuated with HC1006 plasma |
| GSM873848 | stimuated with HC272 plasma |
| GSM873849 | stimuated with HC285 plasma |
| GSM873850 | stimuated with HC233 plasma |
| GSM87385 | stimuated with gram-positive pneumonia patient 1353 plasma |
| GSM873852 | stimuated with gram-positive pneumonia patient 1382 plasma |
| GSM873853 | stimuated with gram-positive pneumonia patient 1403 plasma |
| GSM873854 | stimuated with gram-positive pneumonia patient 1410 plasma |
| GSM873855 | stimuated with gram-positive pneumonia patient 1412 plasma |
| GSM873856 | stimuated with gram-positive pneumonia patient 1224 plasma |
| GSM873857 | stimuated with gram-positive pneumonia patient 1275 plasma |
| GSM873858 | stimuated with gram-positive pneumonia patient 1287 plasma |
| GSM873859 | stimuated with gram-positive pneumonia patient 1325 plasma |
| GSM873860 | stimuated with gram-positive pneumonia patient 1344 plasma |