4ArrayExpress Uploader0humanstimuated with AutoB1S1 plasmastimuated with AutoB1S2 plasmastimuated with AutoB1S3 plasmastimuated with AutoB3W1 plasmastimuated with AutoB3W1+2 plasmastimulated with CF4017 plasmastimulated with CF4024 plasmastimulated with CF4026 plasmastimulated with CF4045 plasmastimulated with CF4047 plasmastimulated with CF4087 plasmastimulated with CF4091 plasmastimulated with CF4107 plasmastimulated with CF4088 plasmastimulated with CF4133 plasmastimulated with CF4138 plasmastimulated with CF4157 plasmastimulated with CF4184 plasmastimulated with CF4256 plasmastimulated with CF4265 plasmastimulated with CF4271 plasmastimulated with CF4297 plasmastimulated with CF4304 plasmastimulated with CF4305 plasmastimulated with CF4285 plasmastimulated with HC1271 plasmastimulated with HC1365 plasmastimulated with HC1301 plasmastimulated with HC1249 plasmastimulated with HC1265 plasmastimulated with HC2300 plasmastimulated with HC1259 plasmastimulated with HC1369 plasmastimulated with HC381 plasmastimulated with HC1534 plasmastimulated with HC1730 plasmastimulated with HCy217 plasmastimulated with HCy226 plasmastimulated with HCy252 plasmastimulated with HCy2301 plasmastimulated with HCy294 plasmastimulated with HCy295 plasmastimulated with HCy385 plasmastimulated with HCy390 plasmastimulated with HCy393 plasmastimulated with HCy1006 plasmastimulated with HCy233 plasmastimulated with HCy284 plasmastimulated with HCy1837 plasma4415arrayexpress_sidhttp://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-35711The complex milieu of inflammatory mediators associated with many diseases is often too dilute to directly measure in the periphery,.../profile/8773/arrayexpressuploader149cystic fibrosisperipheraltractDec.12, 2014Falsetranscriptional-signatures-as-a-disease-specific-aE-GEOD-35711_A-AFFY-44Transcriptional Signatures as a Disease-Specific and Predictive Inflammatory Biomarker for Type 1 Diabetes [CF_S1S3_5Auto_20CF_10HC]Sep.19, 2014The complex milieu of inflammatory mediators associated with many diseases is often too dilute to directly measure in the periphery, necessitating development of more sensitive measurements suitable for mechanistic studies, earlier diagnosis, guiding selection of therapy, and monitoring interventions. Previously, we determined that plasma of recent-onset (RO) Type 1 diabetes (T1D) patients induce a proinflammatory transcriptional signature in fresh peripheral blood mononuclear cells (PBMC) relative to that of unrelated healthy controls (HC). Here, using an optimized cryopreserved PBMC-based protocol, we compared the signature found between unrelated healthy controls and non-diabetic cystic fibrosis patients possessing Pseudomonas aeruginosa pulmonary tract infection. UPN727 cells were stimulated with autologous plasma (n=5), unrelated healthy control plasma (n=24), or plasma from patients with cystic fibrosis possessing Psuedomonas aeruginosa pulmonary tract infection (n=20). Gene expression analysis was perfromed in order to evaluate the transcriptional signature associated with cystic fibrosis.E-GEOD-35711http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-35711/samples/