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Home › Dataset Library › Gene expression profiling of Myf5-Cre;Smad4flox/flox mouse models of tongue development

Dataset: Gene expression profiling of Myf5-Cre;Smad4flox/flox mouse models of tongue development

We investigated Smad4-mediated TGF-beta signaling in the development of occipital somite-derived myogenic progenitors during tongue...

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We investigated Smad4-mediated TGF-beta signaling in the development of occipital somite-derived myogenic progenitors during tongue morphogenesis by comparing the transcriptomes of tongue derived from Myf5-Cre;Smad4flox/flox mutant and Myf5-Cre;Smad4flox/+ control mice at day E13.5. Based on gene expression profiles and functional studies, we elucidated the influences Smad4 activity and TGF-beta signaling have on the gene expression profiles underlying tongue development. The data are consistent with the hypothesis that TGF-beta-Smad4-FGF6 signaling cascade plays a crucial role in myogenic cell fate determination and lineage progression during tongue myogenesis. We obtained RNA samples from tongue tissues of mutant and control mouse embryos (C57BL/6J) at day E13.5 RNA and subjected them to analysis on Affymetrix GeneChip Mouse Genome 430 2.0 Arrays.

Species:
mouse

Samples:
12

Source:
E-GEOD-35357

Updated:
Dec.12, 2014

Registered:
Nov.12, 2014


Factors: (via ArrayExpress)
Sample GENOTYPE
GSM866738 Myf5-Cre;Smad4flox/flox
GSM866738 Myf5-Cre;Smad4flox/flox
GSM866738 Myf5-Cre;Smad4flox/flox
GSM866738 Myf5-Cre;Smad4flox/flox
GSM866738 Myf5-Cre;Smad4flox/flox
GSM866738 Myf5-Cre;Smad4flox/flox
GSM866744 Myf5-Cre;Smad4flox/+
GSM866744 Myf5-Cre;Smad4flox/+
GSM866744 Myf5-Cre;Smad4flox/+
GSM866744 Myf5-Cre;Smad4flox/+
GSM866744 Myf5-Cre;Smad4flox/+
GSM866744 Myf5-Cre;Smad4flox/+

Tags

  • cell
  • genome
  • occipital
  • somite
  • tongue

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