ArrayExpress Uploader0mouseMyf5-Cre;Smad4flox/floxMyf5-Cre;Smad4flox/floxMyf5-Cre;Smad4flox/floxMyf5-Cre;Smad4flox/floxMyf5-Cre;Smad4flox/floxMyf5-Cre;Smad4flox/floxMyf5-Cre;Smad4flox/+Myf5-Cre;Smad4flox/+Myf5-Cre;Smad4flox/+Myf5-Cre;Smad4flox/+Myf5-Cre;Smad4flox/+Myf5-Cre;Smad4flox/+6764arrayexpress_sid6We investigated Smad4-mediated TGF-beta signaling in the development of occipital somite-derived myogenic progenitors during tongue...E-GEOD-35357/profile/8773/arrayexpressuploader112cellgenomeoccipitalsomitetongueDec.12, 2014Falsegene-expression-profiling-of-myf5-cresmad4floxfloxE-GEOD-35357_A-AFFY-45Gene expression profiling of Myf5-Cre;Smad4flox/flox mouse models of tongue developmentNov.12, 2014We investigated Smad4-mediated TGF-beta signaling in the development of occipital somite-derived myogenic progenitors during tongue morphogenesis by comparing the transcriptomes of tongue derived from Myf5-Cre;Smad4flox/flox mutant and Myf5-Cre;Smad4flox/+ control mice at day E13.5. Based on gene expression profiles and functional studies, we elucidated the influences Smad4 activity and TGF-beta signaling have on the gene expression profiles underlying tongue development. The data are consistent with the hypothesis that TGF-beta-Smad4-FGF6 signaling cascade plays a crucial role in myogenic cell fate determination and lineage progression during tongue myogenesis. We obtained RNA samples from tongue tissues of mutant and control mouse embryos (C57BL/6J) at day E13.5 RNA and subjected them to analysis on Affymetrix GeneChip Mouse Genome 430 2.0 Arrays.http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-35357http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-35357/samples/