{"owner": "ArrayExpress Uploader", "pop_total": 0, "species": "mouse", "factors": [{"GSM866738": {"GENOTYPE": "Myf5-Cre;Smad4flox/flox"}}, {"GSM866738": {"GENOTYPE": "Myf5-Cre;Smad4flox/flox"}}, {"GSM866738": {"GENOTYPE": "Myf5-Cre;Smad4flox/flox"}}, {"GSM866738": {"GENOTYPE": "Myf5-Cre;Smad4flox/flox"}}, {"GSM866738": {"GENOTYPE": "Myf5-Cre;Smad4flox/flox"}}, {"GSM866738": {"GENOTYPE": "Myf5-Cre;Smad4flox/flox"}}, {"GSM866744": {"GENOTYPE": "Myf5-Cre;Smad4flox/+"}}, {"GSM866744": {"GENOTYPE": "Myf5-Cre;Smad4flox/+"}}, {"GSM866744": {"GENOTYPE": "Myf5-Cre;Smad4flox/+"}}, {"GSM866744": {"GENOTYPE": "Myf5-Cre;Smad4flox/+"}}, {"GSM866744": {"GENOTYPE": "Myf5-Cre;Smad4flox/+"}}, {"GSM866744": {"GENOTYPE": "Myf5-Cre;Smad4flox/+"}}], "id": 6764, "ownerprofile_id": "arrayexpress_sid", "platform": 6, "summary_wrapped": "We investigated Smad4-mediated TGF-beta signaling in the development of occipital somite-derived myogenic progenitors during tongue...", "geo_gse_id": "E-GEOD-35357", "owner_profile": "/profile/8773/arrayexpressuploader", "factor_count": 1, "sample_count": 12, "tags": ["cell", "genome", "occipital", "somite", "tongue"], "lastmodified": "Dec.12, 2014", "is_default": false, "geo_gds_id": "", "slug": "gene-expression-profiling-of-myf5-cresmad4floxflox", "geo_id_plat": "E-GEOD-35357_A-AFFY-45", "name": "Gene expression profiling of Myf5-Cre;Smad4flox/flox mouse models of tongue development", "created": "Nov.12, 2014", "summary": "We investigated Smad4-mediated TGF-beta signaling in the development of occipital somite-derived myogenic progenitors during tongue morphogenesis by comparing the transcriptomes of tongue derived from Myf5-Cre;Smad4flox/flox mutant and Myf5-Cre;Smad4flox/+ control mice at day E13.5. Based on gene expression profiles and functional studies, we elucidated the influences Smad4 activity and TGF-beta signaling have on the gene expression profiles underlying tongue development. The data are consistent with the hypothesis that TGF-beta-Smad4-FGF6 signaling cascade plays a crucial role in myogenic cell fate determination and lineage progression during tongue myogenesis. We obtained RNA samples from tongue tissues of mutant and control mouse embryos (C57BL/6J) at day E13.5 RNA and subjected them to analysis on Affymetrix GeneChip Mouse Genome 430 2.0 Arrays.", "source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-35357", "sample_source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-35357/samples/"}