ArrayExpress Uploader0human55maleHealthy donorUntreatedalphaMEM+10%FBS+FGF2(1ng/mL)53maleHealthy donorUntreatedalphaMEM+10%FBS+FGF2(1ng/mL)30maleHealthy donorUntreatedalphaMEM+10%FBS+FGF2(1ng/mL)68femaleHealthy donorUntreatedalphaMEM+10%FBS+FGF2(1ng/mL)53maleHealthy donorUntreatedalphaMEM+10%FBS+FGF2(1ng/mL)78femaleHealthy donorUntreatedalphaMEM+10%FBS+FGF2(1ng/mL)68maleFollicular Lymphoma patientUntreatedalphaMEM+10%FBS+FGF2(1ng/mL)55maleFollicular Lymphoma patientUntreatedalphaMEM+10%FBS+FGF2(1ng/mL)76maleFollicular Lymphoma patientUntreatedalphaMEM+10%FBS+FGF2(1ng/mL)53femaleFollicular Lymphoma patientUntreatedalphaMEM+10%FBS+FGF2(1ng/mL)73maleFollicular Lymphoma patientUntreatedalphaMEM+10%FBS+FGF2(1ng/mL)61maleFollicular Lymphoma patientUntreatedalphaMEM+10%FBS+FGF2(1ng/mL)47maleFollicular Lymphoma patientUntreatedalphaMEM+10%FBS+FGF2(1ng/mL)56maleFollicular Lymphoma patientUntreatedalphaMEM+10%FBS+FGF2(1ng/mL)42maleFollicular Lymphoma patientUntreatedalphaMEM+10%FBS+FGF2(1ng/mL)66femaleFollicular Lymphoma patientUntreatedalphaMEM+10%FBS+FGF2(1ng/mL)55maleHealthy donorUntreatedalphaMEM+10%FBS+FGF2(1ng/mL)53maleHealthy donorUntreatedalphaMEM+10%FBS+FGF2(1ng/mL)30maleHealthy donorUntreatedalphaMEM+10%FBS+FGF2(1ng/mL)68femaleHealthy donorUntreatedalphaMEM+10%FBS+FGF2(1ng/mL)53maleHealthy donorUntreatedalphaMEM+10%FBS+FGF2(1ng/mL)78femaleHealthy donorUntreatedalphaMEM+10%FBS+FGF2(1ng/mL)55maleHealthy donorStimulated by TNF+LT for 3 daysRPMI1640+10%FBS53maleHealthy donorStimulated by TNF+LT for 3 daysRPMI1640+10%FBS30maleHealthy donorStimulated by TNF+LT for 3 daysRPMI1640+10%FBS68femaleHealthy donorStimulated by TNF+LT for 3 daysRPMI1640+10%FBS53maleHealthy donorStimulated by TNF+LT for 3 daysRPMI1640+10%FBS78femaleHealthy donorStimulated by TNF+LT for 3 daysRPMI1640+10%FBS4394arrayexpress_sid4Human bone marrow mesenchymal stromal cells (BM-MSC) could be committed toward a functional lymphoid-like stroma by a combination of...E-GEOD-35331/profile/8773/arrayexpressuploader528bonebone marrowcelllymphlymph nodestromaDec.12, 2014FalseE-GEOD-35331_A-AFFY-44expression-data-from-bone-marrow-mesenchymal-stromExpression data from Bone-Marrow Mesenchymal Stromal Cells (BM-MSC) from Follicular Lymphoma patient (FL) or Healthy Donor (HD).Sep.19, 2014Human bone marrow mesenchymal stromal cells (BM-MSC) could be committed toward a functional lymphoid-like stroma by a combination of TNFalpha (TNF) and Lymphotoxin alpha1/beta2 (LT) (Amé-Thomas et al Blood 2007). Bone marrow and lymph node stromal cells support FL malignant cell recruitment and growth in particular after comittment to a lymphoid-like differentiation in vitro. In addition, more than 70% of FL patients exhibit a bone marrow involvment at diagnosis. We delineate using Affymetrix U133+2.0 microarrays the gene expression profile of BM-MSC obtained from FL patients (FL-MSC) and age-matched healthy donors (HD-MSC) in order to identify a specific FL-MSC signature. In addition, we used Affymetrix microarrays to define the gene expression signature of lymphoid-like stromal cells obtained from HD-MSC by treatment with TNF/LT in vitro. This TNF/LT signature was then used to interpret the gene expression profile of FL-MSC. GEP was performed on 10 BM-MSC from FL patients and 6 from healthy donors, treated or not with TNF(10 ng/mL)/LT(100ng/mL)http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-35331http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-35331/samples/