ArrayExpress Uploader0humanRehnot specifiedReh0.5 uM vorinostatReh1 uM vorinostatReh2.5 uM vorinostatRS4not specifiedRS41 uM vorinostatMV4not specifiedMV41 uM vorinostatnot specifiednot specifiednot specified1 uM vorinostatnot specifiednot specifiednot specified1 uM vorinostatnot specifiednot specifiednot specified1 uM vorinostat4381arrayexpress_sid4Reversing gene expression signatures in relapsed patient may restore chemosensitivity. We demonstrate that the histone deacetylase...E-GEOD-34880/profile/8773/arrayexpressuploader214cellhistoneleukemiaDec.12, 2014Falseepigenetic-reprogramming-in-relapsed-childhood-allE-GEOD-34880_A-AFFY-44Epigenetic reprogramming in relapsed childhood ALLSep.19, 2014Reversing gene expression signatures in relapsed patient may restore chemosensitivity. We demonstrate that the histone deacetylase inhibitor vorinostat not only reprograms the aberrant gene expression profile of relapsed blasts but is synergistic when applied prior to chemotherapy in primary patient samples and leukemia cell lines Primary patient samples were collected from patients treated at the New York University Medical Center and from the Children’s Oncology Group (COG) cell bank,RNA was isolated from three primary patient samples and three B-lineage leukemia cell lines with or without treatment with vorinostat for 24 hours.http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-34880http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-34880/samples/