{"owner": "ArrayExpress Uploader", "pop_total": 0, "id": 1266, "factors": [{"GSM856280": {"FLT3 STATUS": "WT", "SET": "test", "NPM STATUS": "wild-type", "FAB CLASSIFICATION": "M4e"}}, {"GSM856279": {"FLT3 STATUS": "WT", "SET": "test", "NPM STATUS": "wild-type", "FAB CLASSIFICATION": "M4"}}, {"GSM856278": {"FLT3 STATUS": "internal tandem duplication (ITD)", "SET": "test", "NPM STATUS": "wild-type", "FAB CLASSIFICATION": "M4"}}, {"GSM856278": {"FLT3 STATUS": "internal tandem duplication (ITD)", "SET": "test", "NPM STATUS": "wild-type", "FAB CLASSIFICATION": "M4"}}, {"GSM856278": {"FLT3 STATUS": "internal tandem duplication (ITD)", "SET": "test", "NPM STATUS": "wild-type", "FAB CLASSIFICATION": "M4"}}, {"GSM856275": {"FLT3 STATUS": "WT", "SET": "test", "NPM STATUS": "wild-type", "FAB CLASSIFICATION": "M2"}}, {"GSM856275": {"FLT3 STATUS": "WT", "SET": "test", "NPM STATUS": "wild-type", "FAB CLASSIFICATION": "M2"}}, {"GSM856273": {"FLT3 STATUS": "WT", "SET": "test", "NPM STATUS": "wild-type", "FAB CLASSIFICATION": "M0"}}, {"GSM856272": {"FLT3 STATUS": "WT", "SET": "test", "NPM STATUS": "wild-type", "FAB CLASSIFICATION": "M1"}}, {"GSM85627": {"FLT3 STATUS": "internal tandem duplication (ITD)", "SET": "test", "NPM STATUS": "wild-type", "FAB CLASSIFICATION": "M1"}}, {"GSM856270": {"FLT3 STATUS": "internal tandem duplication (ITD)", "SET": "test", "NPM STATUS": "wild-type", "FAB CLASSIFICATION": "M5a"}}, {"GSM856269": {"FLT3 STATUS": "internal tandem duplication (ITD)/D835 mutation", "SET": "test", "NPM STATUS": "mutated", "FAB CLASSIFICATION": "M5b"}}, {"GSM856268": {"FLT3 STATUS": "internal tandem duplication (ITD)", "SET": "test", "NPM STATUS": "mutated", "FAB CLASSIFICATION": "M5b"}}, {"GSM856267": {"FLT3 STATUS": "WT", "SET": "test", "NPM STATUS": "mutated", "FAB CLASSIFICATION": "M4"}}, {"GSM856266": {"FLT3 STATUS": "internal tandem duplication (ITD)", "SET": "test", "NPM STATUS": "mutated", "FAB CLASSIFICATION": "M4"}}, {"GSM856265": {"FLT3 STATUS": "WT", "SET": "test", "NPM STATUS": "mutated", "FAB CLASSIFICATION": "M1"}}, {"GSM856264": {"FLT3 STATUS": "WT", "SET": "test", "NPM STATUS": "mutated", "FAB CLASSIFICATION": "M0"}}, {"GSM856263": {"FLT3 STATUS": "WT", "SET": "test", "NPM STATUS": "mutated", "FAB CLASSIFICATION": "M5b"}}, {"GSM856263": {"FLT3 STATUS": "WT", "SET": "test", "NPM STATUS": "mutated", "FAB CLASSIFICATION": "M5b"}}, {"GSM856263": {"FLT3 STATUS": "WT", "SET": "test", "NPM STATUS": "mutated", "FAB CLASSIFICATION": "M5b"}}, {"GSM856263": {"FLT3 STATUS": "WT", "SET": "test", "NPM STATUS": "mutated", "FAB CLASSIFICATION": "M5b"}}, {"GSM856268": {"FLT3 STATUS": "internal tandem duplication (ITD)", "SET": "test", "NPM STATUS": "mutated", "FAB CLASSIFICATION": "M5b"}}, {"GSM856268": {"FLT3 STATUS": "internal tandem duplication (ITD)", "SET": "test", "NPM STATUS": "mutated", "FAB CLASSIFICATION": "M5b"}}, {"GSM856257": {"FLT3 STATUS": "WT", "SET": "test", "NPM STATUS": "mutated", "FAB CLASSIFICATION": "M5a"}}, {"GSM856256": {"FLT3 STATUS": "internal tandem duplication (ITD)", "SET": "test", "NPM STATUS": "mutated", "FAB CLASSIFICATION": "M5a"}}, {"GSM856256": {"FLT3 STATUS": "internal tandem duplication (ITD)", "SET": "test", "NPM STATUS": "mutated", "FAB CLASSIFICATION": "M5a"}}, {"GSM856254": {"FLT3 STATUS": "internal tandem duplication (ITD)", "SET": "test", "NPM STATUS": "mutated", "FAB CLASSIFICATION": "M5"}}, {"GSM856267": {"FLT3 STATUS": "WT", "SET": "test", "NPM STATUS": "mutated", "FAB CLASSIFICATION": "M4"}}, {"GSM856252": {"FLT3 STATUS": "internal tandem duplication (ITD)/D835 mutation", "SET": "test", "NPM STATUS": "mutated", "FAB CLASSIFICATION": "M4"}}, {"GSM856266": {"FLT3 STATUS": "internal tandem duplication (ITD)", "SET": "test", "NPM STATUS": "mutated", "FAB CLASSIFICATION": "M4"}}, {"GSM856266": {"FLT3 STATUS": "internal tandem duplication (ITD)", "SET": "test", "NPM STATUS": "mutated", "FAB CLASSIFICATION": "M4"}}, {"GSM856266": {"FLT3 STATUS": "internal tandem duplication (ITD)", "SET": "test", "NPM STATUS": "mutated", "FAB CLASSIFICATION": "M4"}}, {"GSM856248": {"FLT3 STATUS": "D835 mutation", "SET": "test", "NPM STATUS": "mutated", "FAB CLASSIFICATION": "M4"}}, {"GSM856247": {"FLT3 STATUS": "WT", "SET": "test", "NPM STATUS": "mutated", "FAB CLASSIFICATION": "M2"}}, {"GSM856247": {"FLT3 STATUS": "WT", "SET": "test", "NPM STATUS": "mutated", "FAB CLASSIFICATION": "M2"}}, {"GSM856245": {"FLT3 STATUS": "internal tandem duplication (ITD)", "SET": "test", "NPM STATUS": "mutated", "FAB CLASSIFICATION": "M2"}}, {"GSM856244": {"FLT3 STATUS": "D835 mutation", "SET": "test", "NPM STATUS": "mutated", "FAB CLASSIFICATION": "M2"}}, {"GSM856265": {"FLT3 STATUS": "WT", "SET": "test", "NPM STATUS": "mutated", "FAB CLASSIFICATION": "M1"}}, {"GSM856242": {"FLT3 STATUS": "internal tandem duplication (ITD)", "SET": "test", "NPM STATUS": "mutated", "FAB CLASSIFICATION": "M1"}}, {"GSM85624": {"FLT3 STATUS": "internal tandem duplication (ITD)", "SET": "training", "NPM STATUS": "wild-type", "FAB CLASSIFICATION": "M2"}}, {"GSM856240": {"FLT3 STATUS": "internal tandem duplication (ITD)", "SET": "training", "NPM STATUS": "wild-type", "FAB CLASSIFICATION": "M5a"}}, {"GSM856239": {"FLT3 STATUS": "WT", "SET": "training", "NPM STATUS": "wild-type", "FAB CLASSIFICATION": "M4"}}, {"GSM856239": {"FLT3 STATUS": "WT", "SET": "training", "NPM STATUS": "wild-type", "FAB CLASSIFICATION": "M4"}}, {"GSM856237": {"FLT3 STATUS": "WT", "SET": "training", "NPM STATUS": "wild-type", "FAB CLASSIFICATION": "M2"}}, {"GSM856236": {"FLT3 STATUS": "WT", "SET": "training", "NPM STATUS": "wild-type", "FAB CLASSIFICATION": "M1"}}, {"GSM856236": {"FLT3 STATUS": "WT", "SET": "training", "NPM STATUS": "wild-type", "FAB CLASSIFICATION": "M1"}}, {"GSM856236": {"FLT3 STATUS": "WT", "SET": "training", "NPM STATUS": "wild-type", "FAB CLASSIFICATION": "M1"}}, {"GSM856233": {"FLT3 STATUS": "WT", "SET": "training", "NPM STATUS": "wild-type", "FAB CLASSIFICATION": "M0"}}, {"GSM856232": {"FLT3 STATUS": "internal tandem duplication (ITD)", "SET": "training", "NPM STATUS": "wild-type", "FAB CLASSIFICATION": "M0"}}, {"GSM85623": {"FLT3 STATUS": "WT", "SET": "training", "NPM STATUS": "mutated", "FAB CLASSIFICATION": "M5b"}}, {"GSM856230": {"FLT3 STATUS": "D835 mutation", "SET": "training", "NPM STATUS": "mutated", "FAB CLASSIFICATION": "M5b"}}, {"GSM856230": {"FLT3 STATUS": "D835 mutation", "SET": "training", "NPM STATUS": "mutated", "FAB CLASSIFICATION": "M5b"}}, {"GSM856228": {"FLT3 STATUS": "WT", "SET": "training", "NPM STATUS": "mutated", "FAB CLASSIFICATION": "M5a"}}, {"GSM856228": {"FLT3 STATUS": "WT", "SET": "training", "NPM STATUS": "mutated", "FAB CLASSIFICATION": "M5a"}}, {"GSM856228": {"FLT3 STATUS": "WT", "SET": "training", "NPM STATUS": "mutated", "FAB CLASSIFICATION": "M5a"}}, {"GSM856225": {"FLT3 STATUS": "WT", "SET": "training", "NPM STATUS": "mutated", "FAB CLASSIFICATION": "M4"}}, {"GSM856225": {"FLT3 STATUS": "WT", "SET": "training", "NPM STATUS": "mutated", "FAB CLASSIFICATION": "M4"}}, {"GSM856223": {"FLT3 STATUS": "internal tandem duplication (ITD)", "SET": "training", "NPM STATUS": "mutated", "FAB CLASSIFICATION": "M4"}}, {"GSM856223": {"FLT3 STATUS": "internal tandem duplication (ITD)", "SET": "training", "NPM STATUS": "mutated", "FAB CLASSIFICATION": "M4"}}, {"GSM85622": {"FLT3 STATUS": "WT", "SET": "training", "NPM STATUS": "mutated", "FAB CLASSIFICATION": "M2"}}, {"GSM85622": {"FLT3 STATUS": "WT", "SET": "training", "NPM STATUS": "mutated", "FAB CLASSIFICATION": "M2"}}, {"GSM85622": {"FLT3 STATUS": "WT", "SET": "training", "NPM STATUS": "mutated", "FAB CLASSIFICATION": "M2"}}, {"GSM85622": {"FLT3 STATUS": "WT", "SET": "training", "NPM STATUS": "mutated", "FAB CLASSIFICATION": "M2"}}, {"GSM856217": {"FLT3 STATUS": "internal tandem duplication (ITD)", "SET": "training", "NPM STATUS": "mutated", "FAB CLASSIFICATION": "M2"}}, {"GSM856217": {"FLT3 STATUS": "internal tandem duplication (ITD)", "SET": "training", "NPM STATUS": "mutated", "FAB CLASSIFICATION": "M2"}}, {"GSM856217": {"FLT3 STATUS": "internal tandem duplication (ITD)", "SET": "training", "NPM STATUS": "mutated", "FAB CLASSIFICATION": "M2"}}, {"GSM856217": {"FLT3 STATUS": "internal tandem duplication (ITD)", "SET": "training", "NPM STATUS": "mutated", "FAB CLASSIFICATION": "M2"}}, {"GSM856217": {"FLT3 STATUS": "internal tandem duplication (ITD)", "SET": "training", "NPM STATUS": "mutated", "FAB CLASSIFICATION": "M2"}}, {"GSM856217": {"FLT3 STATUS": "internal tandem duplication (ITD)", "SET": "training", "NPM STATUS": "mutated", "FAB CLASSIFICATION": "M2"}}, {"GSM8562": {"FLT3 STATUS": "WT", "SET": "training", "NPM STATUS": "mutated", "FAB CLASSIFICATION": "M1"}}, {"GSM8562": {"FLT3 STATUS": "WT", "SET": "training", "NPM STATUS": "mutated", "FAB CLASSIFICATION": "M1"}}, {"GSM8562": {"FLT3 STATUS": "WT", "SET": "training", "NPM STATUS": "mutated", "FAB CLASSIFICATION": "M1"}}, {"GSM856208": {"FLT3 STATUS": "internal tandem duplication (ITD)", "SET": "training", "NPM STATUS": "mutated", "FAB CLASSIFICATION": "M1"}}, {"GSM856208": {"FLT3 STATUS": "internal tandem duplication (ITD)", "SET": "training", "NPM STATUS": "mutated", "FAB CLASSIFICATION": "M1"}}, {"GSM856208": {"FLT3 STATUS": "internal tandem duplication (ITD)", "SET": "training", "NPM STATUS": "mutated", "FAB CLASSIFICATION": "M1"}}, {"GSM856208": {"FLT3 STATUS": "internal tandem duplication (ITD)", "SET": "training", "NPM STATUS": "mutated", "FAB CLASSIFICATION": "M1"}}, {"GSM856208": {"FLT3 STATUS": "internal tandem duplication (ITD)", "SET": "training", "NPM STATUS": "mutated", "FAB CLASSIFICATION": "M1"}}, {"GSM856208": {"FLT3 STATUS": "internal tandem duplication (ITD)", "SET": "training", "NPM STATUS": "mutated", "FAB CLASSIFICATION": "M1"}}], "ownerprofile_id": "arrayexpress_sid", "platform": 3, "summary_wrapped": "Approximately one third of acute myeloid leukemias (AMLs) are characterized by aberrant cytoplasmic localization of Nucleophosmin (NPMc+...", "pubmed_id": 15831697, "geo_gse_id": "E-GEOD-34860", "owner_profile": "/profile/8773/arrayexpressuploader", "factor_count": 4, "sample_count": 78, "tags": ["cell", "cell phenotype", "stem cell", "tyrosine"], "lastmodified": "Dec.12, 2014", "is_default": false, "geo_gds_id": "", "slug": "gene-expression-profiling-in-acute-myeloid-leukemi", "geo_id_plat": "E-GEOD-34860_A-AFFY-33", "name": "Gene expression profiling in acute myeloid leukemia with mutated NPM", "created": "Jun.18, 2014", "summary": "Approximately one third of acute myeloid leukemias (AMLs) are characterized by aberrant cytoplasmic localization of Nucleophosmin (NPMc+ AML), consequent to mutations in the NPM putative nucleolar localization signal.  These events are mutually exclusive with the major AML-associated chromosomal rearrangements, and are frequently associated with normal karyotype, Fms-like tyrosine kinase (FLT3) mutations and multilineage involvement. We report the gene expression profiles of 78 de novo AMLs (72 with normal karyotype; 6 with non-major chromosomal abnormalities) that were characterized for the subcellular localization and mutation status of NPM. Unsupervised clustering clearly separated NPMc+ from NPMc- AMLs, regardless of the presence of FLT3 mutations or non-major chromosomal rearrangements, supporting the concept that NPMc+ AML represents a distinct entity. The molecular signature of NPMc+ AML includes up-regulation of several genes putatively involved in the maintenance of a stem cell phenotype, suggesting that NPMc+ AML may derive from a multipotent hematopoietic progenitor. 78 de novo AMLs, negative for AML-associated chromosomal translocations at the cytogenetic and/or molecular level.", "source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-34860", "species": "human", "sample_source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-34860/samples/"}