{"owner": "ArrayExpress Uploader", "pop_total": 0, "species": "mouse", "factors": [{"GSM852964": {"VARIATION": "WT"}}, {"GSM852964": {"VARIATION": "WT"}}, {"GSM852964": {"VARIATION": "WT"}}, {"GSM852967": {"VARIATION": "Alb/AEG-1 Transgenic"}}, {"GSM852967": {"VARIATION": "Alb/AEG-1 Transgenic"}}, {"GSM852967": {"VARIATION": "Alb/AEG-1 Transgenic"}}], "id": 8595, "ownerprofile_id": "arrayexpress_sid", "platform": 8, "summary_wrapped": "Astrocyte elevated gene-1 (AEG-1) as a positive inducer of hepatocellular carcinoma (HCC). Transgenic mice with hepatocyte-specific...", "geo_gse_id": "E-GEOD-34669", "owner_profile": "/profile/8773/arrayexpressuploader", "factor_count": 1, "sample_count": 6, "tags": ["astrocyte", "carcinoma", "hepatocellular carcinoma", "hepatocyte", "liver"], "lastmodified": "Dec.12, 2014", "is_default": false, "geo_gds_id": "", "slug": "astrocyte-elevated-gene-1-aeg-1-promotes-hepatocar", "geo_id_plat": "E-GEOD-34669_A-AFFY-36", "name": "Astrocyte elevated gene-1 (AEG-1) promotes hepatocarcinogenesis: novel insights from a mouse model", "created": "Nov.24, 2014", "summary": "Astrocyte elevated gene-1 (AEG-1) as a positive inducer of hepatocellular carcinoma (HCC). Transgenic mice with hepatocyte-specific expression of AEG-1 were challenged with N-nitrosodiethylamine (DEN) and developed multinodular HCC with steatotic features. Thus, we have identified the follwoing AEG-1 functions: induction of steatosis, inhibition of senescence and activation of coagulation pathway to augment an aggressive hepatocarcinogenic phenotype. Transgenic Mice liver tumors compared against WT mice liver tumors.", "source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-34669", "sample_source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-34669/samples/"}