{"owner": "ArrayExpress Uploader", "ownerprofile_id": "arrayexpress_sid", "species": "human", "factors": [{"GSM841045": {"TREATMENT": "control"}}, {"GSM841046": {"TREATMENT": "Tamoxifen induced"}}, {"GSM841047": {"TREATMENT": "shRNA SAE2"}}, {"GSM841048": {"TREATMENT": "Tamoxifen+shRNA"}}, {"GSM841045": {"TREATMENT": "control"}}, {"GSM841046": {"TREATMENT": "Tamoxifen induced"}}, {"GSM841047": {"TREATMENT": "shRNA SAE2"}}, {"GSM841048": {"TREATMENT": "Tamoxifen+shRNA"}}, {"GSM841045": {"TREATMENT": "control"}}, {"GSM841046": {"TREATMENT": "Tamoxifen induced"}}, {"GSM841047": {"TREATMENT": "shRNA SAE2"}}, {"GSM841048": {"TREATMENT": "Tamoxifen+shRNA"}}], "id": 4328, "pop_total": 0, "platform": 4, "summary_wrapped": "Myc is an oncogenic transcription factor frequently dysregulated in human cancer. To identify pathways supporting the Myc oncogenic...", "geo_gse_id": "E-GEOD-34055", "owner_profile": "/profile/8773/arrayexpressuploader", "factor_count": 1, "sample_count": 12, "tags": ["cancer", "genome", "spindle"], "lastmodified": "Dec.12, 2014", "is_default": false, "geo_id_plat": "E-GEOD-34055_A-AFFY-44", "slug": "a-sumoylation-dependent-transcriptional-subprogram", "geo_gds_id": "", "name": "A sumoylation-dependent transcriptional subprogram is required for Myc-driven tumorigenesis", "created": "Sep.16, 2014", "summary": "Myc is an oncogenic transcription factor frequently dysregulated in human cancer. To identify pathways supporting the Myc oncogenic program, we employed a genome-wide RNAi screen for Myc-synthetic-lethal (MySL) genes and uncovered a role for the SUMO-activating-enzyme (SAE1/2). Loss of SAE1/2 enzymatic activity drives synthetic lethality with Myc.  Mechanistically, SAE2 inhibition switches a transcriptional subprogram of Myc from activated to repressed. A subset of these SUMOylation-dependent Myc-switchers (SMS genes) governs mitotic spindle function and is required to support the Myc oncogenic program. comparison of 4 treatments: normal HMEC, High Myc in HMEC, SUMO depleted in HMEC, High Myc+Sumo Depleted in HMEC", "source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-34055", "sample_source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-34055/samples/"}