{"owner": "ArrayExpress Uploader", "pop_total": 0, "species": "mouse", "factors": [{"GSM840978 1": {}}, {"GSM840979 1": {}}, {"GSM840980 1": {}}], "id": 8589, "ownerprofile_id": "arrayexpress_sid", "platform": 8, "summary_wrapped": "The A238L gene has been selectively expressed in mouse T lymphocytes using tissue specific promoter, enhancer and locus control region...", "geo_gse_id": "E-GEOD-34048", "owner_profile": "/profile/8773/arrayexpressuploader", "factor_count": 0, "sample_count": 3, "tags": ["lymphoma"], "lastmodified": "Dec.12, 2014", "is_default": false, "geo_gds_id": "", "slug": "transgenic-expression-of-a238l-a-virus-host-modifi", "geo_id_plat": "E-GEOD-34048_A-AFFY-36", "name": "Transgenic Expression of A238L, a Virus Host Modification Protein, in mouse T cells", "created": "Nov.24, 2014", "summary": "The A238L gene has been selectively expressed in mouse T lymphocytes using tissue specific promoter, enhancer and locus control region sequences for CD2. The resulting two independently derived transgenic mice expressed the transgene and developed a metastatic, angiogenic and transplantable CD4+CD8+ CD69- lymphoma. The absence of CD69 from the tumour cells suggests that they were derived from T-cells at a stage prior to positive selection.  In contrast, transgenic mice similarly expressing a mutant A238L, mutA238L, solely inhibiting transcription mediated by NF-\uf06bB, were indistinguishable from wild type mice.  Expression of Rag 1, Rag2, TCRbeta V8.2, CD25, FoxP3, Bcl3, Bcl2 l14, Myc, IL-2, NFAT1, Itk, by purified CD4+CD8+ CD69- thymocytes from A238L transgenic mice was consistent with the phenotype. Similarly evaluated expression profiles of   CD4+CD8+ CD69- thymocytes from the mutant A238L transgenic mice were comparable to those of wild type mice. Purified CD4+CD8+CD69- thymocytes were prepared for wild-type control FVB/N mice, as well as from the FVB/N transgenic mice expressing the A238L and the mutated A238L, mutA238L. Comparisons were performed between the two transgenic mice lines and the control mice.", "source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-34048", "sample_source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-34048/samples/"}