<?xml version="1.0" encoding="ASCII"?>
<biogps><data><item key="owner">ArrayExpress Uploader</item><item key="pop_total">0</item><item key="id">4325</item><item key="factors"><item><item key="GSM840610"><item key="CELL LINE">TC-71</item><item key="CELL LINE RESISTANCE">no IGF-1R drugs resistant</item></item></item><item><item key="GSM840610"><item key="CELL LINE">TC-71</item><item key="CELL LINE RESISTANCE">no IGF-1R drugs resistant</item></item></item><item><item key="GSM840610"><item key="CELL LINE">TC-71</item><item key="CELL LINE RESISTANCE">no IGF-1R drugs resistant</item></item></item><item><item key="GSM840613"><item key="CELL LINE">TC/AEW</item><item key="CELL LINE RESISTANCE">stably resistant to IGF-1R TKI NVP-AEW541</item></item></item><item><item key="GSM840613"><item key="CELL LINE">TC/AEW</item><item key="CELL LINE RESISTANCE">stably resistant to IGF-1R TKI NVP-AEW541</item></item></item><item><item key="GSM840615"><item key="CELL LINE">TC/AVE</item><item key="CELL LINE RESISTANCE">stably resistant to IGF-1R Hab AVE1642 Hab</item></item></item><item><item key="GSM840615"><item key="CELL LINE">TC/AVE</item><item key="CELL LINE RESISTANCE">stably resistant to IGF-1R Hab AVE1642 Hab</item></item></item><item><item key="GSM840617"><item key="CELL LINE">TC/CP</item><item key="CELL LINE RESISTANCE">stably resistant to IGF-1R Hab CP-751,871</item></item></item><item><item key="GSM840617"><item key="CELL LINE">TC/CP</item><item key="CELL LINE RESISTANCE">stably resistant to IGF-1R Hab CP-751,871</item></item></item></item><item key="ownerprofile_id">arrayexpress_sid</item><item key="platform">4</item><item key="summary_wrapped">Ewing's Sarcoma cell lines were made resistant to different IGF-1R drugs to investigate mechanisms and pathways modulated by the...</item><item key="pubmed_id">22798295</item><item key="geo_gse_id">E-GEOD-34027</item><item key="owner_profile">/profile/8773/arrayexpressuploader</item><item key="factor_count">2</item><item key="sample_count">9</item><item key="tags"><item>cell</item><item>line</item><item>sarcoma</item></item><item key="lastmodified">Dec.12, 2014</item><item key="is_default">False</item><item key="geo_gds_id"/><item key="slug">ews-tc-71-cell-lines-igf-1r-resistant</item><item key="geo_id_plat">E-GEOD-34027_A-AFFY-44</item><item key="name">EWS TC-71 cell lines: IGF-1R resistant</item><item key="created">Sep.16, 2014</item><item key="summary">Ewing's Sarcoma cell lines were made resistant to different IGF-1R drugs to investigate mechanisms and pathways modulated by the resistance. EWS TC-71 cell line was exposed to increasing concentration to three different anti-IGF-1R drugs (HAb AVE1642, TKI NVP-AEW541,  HAb CP-751,871, cell lines named respectively as TC/AVE, TC/AEW or TC/CP) for at least six months. Expression profile of resistant cell variants was compared either singularly for each resistance or commonly vs. parental cell line. Two technical replicates for resistant variants and three biological replicated for parental cell were present.</item><item key="source">http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-34027</item><item key="species">human</item><item key="sample_source">http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-34027/samples/</item></data></biogps>
