ArrayExpress Uploader0mousewild type, A2AR+/+FoxP3GFPwild type, A2AR+/+FoxP3GFPA2AR knockout (KO), A2AR-/-FoxP3GFPA2AR knockout (KO), A2AR-/-FoxP3GFPwild type, A2AR+/+FoxP3GFPwild type, A2AR+/+FoxP3GFP6696arrayexpress_sid6The adenosine 2A receptor (A2AR) is expressed on regulatory T cells (Tregs), but the functional significance is currently unknown. We...E-GEOD-34006/profile/8773/arrayexpressuploader16lymphspleenDec.12, 2014Falserole-of-adenosine-2a-receptors-a2ar-on-regulatoryE-GEOD-34006_A-AFFY-45Role of Adenosine 2A Receptors (A2AR) on regulatory T cells (Tregs)Nov.12, 2014The adenosine 2A receptor (A2AR) is expressed on regulatory T cells (Tregs), but the functional significance is currently unknown. We compared the gene expression between wild-type (WT) and A2AR knockout (KO) Tregs and between WT Tregs treated with vehicle or a selective A2AR agonist. FACS-sorted GFP positive Tregs from WT or A2AR KO FoxP3GFP mouse spleen and lymph nodes were incubated 18 hr with vehicle (DMSO), a separate set of WT Tregs were incubated with the selective A2AR agonist ATL1222 10 nM (Dogwood Pharmaceuticals, Inc.) for 18 hr prior to RNA isolation.http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-34006http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-34006/samples/