ArrayExpress Uploader0mouseno DT mock infectedno DT infectedplus DT mock infectedplus DT infected6694arrayexpress_sid6Dendritic cells (DCs) regulate both innate and adaptive immune responses. The role of CD11c-plus DCs in the corneal response to to herpes...E-GEOD-33991/profile/8773/arrayexpressuploader14bonebone marrowdendriticdiphtheriaherpes simplexDec.12, 2014FalseE-GEOD-33991_A-AFFY-45early-responding-dendritic-cells-direct-local-natuEarly responding dendritic cells direct local natural killer response to control HSV-1 infection within the corneaNov.12, 2014Dendritic cells (DCs) regulate both innate and adaptive immune responses. The role of CD11c-plus DCs in the corneal response to to herpes simplex virus-1 (HSV-1) infection was investigated by depleting them prior to infection. Bone marrow cells from CD11c-DTR (C.FVB-Tg(Itgax-DTR/EGFP)57Lan/J) mice were transferred intravenously to irradiated BALB/cJ host mice. After 6 weeks, the bone marrow chimeric host mice were injected with diphtheria toxin (DT) to deplete CD11c-positive cells. Two days after injection, the mice were subjected to a standard corneal infection protocol using HSV-1.http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-33991http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-33991/samples/