ArrayExpress Uploaderarrayexpress_sidhumancontrolcontrol (DMSO)controlcontrol (DMSO)controlcontrol (DMSO)controlcontrol (DMSO)IC30BKM120IC30BKM120IC30BKM120IC30BKM120IC50BKM120IC50BKM120IC50BKM120IC50BKM120IC90 (max)BKM120IC90 (max)BKM120IC90 (max)BKM120IC90 (max)BKM120IC50BEZ235IC50BEZ235IC50BEZ235IC50BEZ235IC90BEZ235IC90BEZ235IC90BEZ235IC90BEZ235maxBEZ235maxBEZ235maxBEZ235maxBEZ235IC50GCD0941IC50GCD0941IC50GCD0941IC50GCD0941IC90GCD0941IC90GCD0941IC90GCD0941IC90GCD0941maxGCD0941maxGCD0941maxGCD0941maxGCD0941430804The goal is the characterization of the off-target activity of BKM120 observed in A2058 human melanoma cell line at IC90 concentration...E-GEOD-33643/profile/8773/arrayexpressuploader240celllinemelanomaDec.12, 2014FalseE-GEOD-33643_A-AFFY-44comparison-of-gene-expression-alterations-inducedComparison of gene expression alterations induced by distinct PI3K inhibitorsSep.16, 2014The goal is the characterization of the off-target activity of BKM120 observed in A2058 human melanoma cell line at IC90 concentration (3.606 µM) but not at lower concentrations. Controls are BEZ235, GDC0941, showing no off-target activity. A secondary objective is the characterizations of drug effects on transcript expression with respect to a control treatment (DMSO) of those PI3K inhibitors. 3 compounds, 3 concentrations per compound treatment, DMSO control treatement, 4 biological replicateshttp://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-33643http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-33643/samples/