Dataset: Comparison of gene expression alterations induced by distinct PI3K inhibitors

The goal is the characterization of the off-target activity of BKM120 observed in A2058 human melanoma cell line at IC90 concentration (3.606 µM) but not at lower concentrations. Controls are BEZ235, GDC0941, showing no off-target activity. A secondary objective is the characterizations of drug effects on transcript expression with respect to a control treatment (DMSO) of those PI3K inhibitors. 3 compounds, 3 concentrations per compound treatment, DMSO control treatement, 4 biological replicates

Species:

human

Samples:

40

Source:

E-GEOD-33643

Updated:

Dec.12, 2014

Registered:

Sep.16, 2014