ArrayExpress Uploaderarrayexpress_sidmousequiescent HG HFSCsTßRII-Hetquiescent bulge HFSCsTßRII-Hettotal skin keratinocytesTßRII-Hetquiescent HG HFSCsTßRII-cKOquiescent bulge HFSCsTßRII-cKOtotal skin keratinocytesTßRII-cKOactivated HG HFSCsTßRII-Hetactivated bulge HFSCsTßRII-Hettotal skin keratinocytesTßRII-Hetaberrantly quiescent HG HFSCs in TßRII-cKO miceTßRII-cKOaberrantly quiescent bulge HFSCs in TßRII-cKO miceTßRII-cKOtotal skin keratinocytesTßRII-cKO667606Hair follicle (HF) regeneration begins when communication between quiescent epithelial stem cells (SCs) and underlying mesenchymal dermal...E-GEOD-33471/profile/8773/arrayexpressuploader212hairhair follicleskinDec.12, 2014FalseE-GEOD-33471_A-AFFY-45paracrine-tgf-signaling-counterbalances-bmp-mediatParacrine TGFß Signaling Counterbalances BMP-Mediated Repression in Hair Follicle Stem Cell ActivationNov.12, 2014Hair follicle (HF) regeneration begins when communication between quiescent epithelial stem cells (SCs) and underlying mesenchymal dermal papillae (DP) generates sufficient activating cues to overcome repressive BMP signals from surrounding niche cells. We uncovered a hitherto unrecognized DP transmitter, TGFβ2, which activates Smad2/3 transiently in HFSCs concomitant with entry into tissue regeneration. We used microarrays to detect the genes specifically affected by TGFß receptor II-deficient mice upon HFSC activation. Hair follicle stem cells (HFSCs) of hair gem (HG) and bulge, and total skin keratinocytes were FACS-purified from the mouse back skin at 2nd telogen-to-anagen transition stages.http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-33471http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-33471/samples/