Dataset: Targeted disruption of the BCL9/beta-catenin complex in cancer

Stabilized Alpha-Helix peptides of BCL9 HD2 (SAH-BCL9) block BCL9 and B9L interactions with beta-catenin and specifically downregulate Wnt target gene expression. RNA from triplicate SAH-BCL9B- and vehicle-treated DLD1 samples (10 µM each for 12 hours) was hybridized to Affymetrix Human U133 Plus 2.0 arrays to asses global gene expression changes.

Species:

human

Samples:

6

Source:

E-GEOD-33143

PubMed:

22914623

Updated:

Dec.12, 2014

Registered:

Sep.16, 2014