ArrayExpress Uploader0humanmetbc_23met_BCNAMetastatic breast cancer biopsymetbc_22met_BCNAMetastatic breast cancer biopsymetbc_21met_BCNAMetastatic breast cancer biopsymetbc_20met_BCNAMetastatic breast cancer biopsymetbc_19met_BCNAMetastatic breast cancer biopsymetbc_18met_BCNAMetastatic breast cancer biopsymetbc_17met_BCNAMetastatic breast cancer biopsymetbc_16met_BCNAMetastatic breast cancer biopsymetbc_15met_BCNAMetastatic breast cancer biopsymetbc_14met_BCNAMetastatic breast cancer biopsymetbc_13met_BCNAMetastatic breast cancer biopsymetbc_12met_BCNAMetastatic breast cancer biopsymetbc_11met_BCNAMetastatic breast cancer biopsymetbc_10met_BCNAMetastatic breast cancer biopsymetbc_9met_BCNAMetastatic breast cancer biopsymetbc_8met_BCNAMetastatic breast cancer biopsymetbc_7met_BCNAMetastatic breast cancer biopsymetbc_6met_BCNAMetastatic breast cancer biopsymetbc_5met_BCNAMetastatic breast cancer biopsymetbc_4met_BCNAMetastatic breast cancer biopsymetbc_3met_BCNAMetastatic breast cancer biopsymetbc_2met_BCNAMetastatic breast cancer biopsymetbc_1met_BCNAMetastatic breast cancer biopsymix_11mix11100breast cancer tumor and liver mixturemix_11mix1190breast cancer tumor and liver mixturemix_11mix1175breast cancer tumor and liver mixturemix_11mix1150breast cancer tumor and liver mixturemix_11mix1125breast cancer tumor and liver mixturemix_11mix1120breast cancer tumor and liver mixturemix_11mix1115breast cancer tumor and liver mixturemix_11mix1110breast cancer tumor and liver mixturemix_11mix115breast cancer tumor and liver mixturemix_11mix11not specifiedbreast cancer tumor and liver mixturemix_10mix11100breast cancer tumor and liver mixturemix_10mix1190breast cancer tumor and liver mixturemix_10mix1175breast cancer tumor and liver mixturemix_10mix1150breast cancer tumor and liver mixturemix_10mix1125breast cancer tumor and liver mixturemix_10mix1120breast cancer tumor and liver mixturemix_10mix1115breast cancer tumor and liver mixturemix_10mix1110breast cancer tumor and 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mixturemix_0_R2mix1tripl85breast cancer tumor and liver mixturemix_0_R2mix1tripl90breast cancer tumor and liver mixturemix_0_R2mix1tripl100breast cancer tumor and liver mixturemix_0_R1mix1tripl5breast cancer tumor and liver mixturemix_0_R1mix1tripl10breast cancer tumor and liver mixturemix_0_R1mix1tripl15breast cancer tumor and liver mixturemix_0_R1mix1tripl20breast cancer tumor and liver mixturemix_0_R1mix1triplnot specifiedbreast cancer tumor and liver mixturemix_0_R1mix1tripl25breast cancer tumor and liver mixturemix_0_R1mix1tripl50breast cancer tumor and liver mixturemix_0_R1mix1tripl70breast cancer tumor and liver mixturemix_0_R1mix1tripl75breast cancer tumor and liver mixturemix_0_R1mix1tripl80breast cancer tumor and liver mixturemix_0_R1mix1tripl85breast cancer tumor and liver mixturemix_0_R1mix1tripl90breast cancer tumor and liver mixturemix_0_R1mix1tripl100breast cancer tumor and liver mixtureliver_31li_val100Liver biopsyliver_30li_val100Liver biopsyliver_29li_val100Liver biopsyliver_28li_val100Liver biopsyliver_27li_val100Liver biopsyliver_26li_val100Liver biopsyliver_25li_val100Liver biopsyliver_24li_val100Liver biopsyliver_23li_val100Liver biopsyliver_22li_val100Liver biopsyliver_21li_dev100Liver biopsyliver_20li_dev100Liver biopsyliver_19li_dev100Liver biopsyliver_18li_dev100Liver biopsyliver_17li_dev100Liver biopsyliver_16li_dev100Liver biopsyliver_15li_dev100Liver biopsyliver_14li_dev100Liver biopsyliver_13li_dev100Liver biopsyliver_12li_dev100Liver biopsyliver_11li_dev100Liver biopsyliver_10li_dev100Liver biopsyliver_9li_dev100Liver biopsyliver_8li_dev100Liver biopsyliver_7li_dev100Liver biopsyliver_6li_dev100Liver biopsyliver_5li_dev100Liver biopsyliver_4li_dev100Liver biopsyliver_3li_dev100Liver biopsyliver_2li_dev100Liver biopsyliver_1li_dev100Liver biopsy2716arrayexpress_sid3PURPOSE: To develop an index capable of detecting and quantifying the extent of liver RNA contamination in liver biopsies of metastatic...E-GEOD-33116/profile/8773/arrayexpressuploader4203breastbreast cancercancerliverDec.12, 2014Falsebreast-cancer-and-liver-tissue-biopsies-used-to-deE-GEOD-33116_A-AFFY-33Breast cancer and liver tissue biopsies used to develop and validate an index for liver contamination in metastatic breast cancerJul.22, 2014PURPOSE: To develop an index capable of detecting and quantifying the extent of liver RNA contamination in liver biopsies of metastatic breast cancer METHODS: We developed a microarray-based gene expression liver index by comparing the expression levels of genes in liver tissue biopsies and in primary breast cancer biopsies. The predictive performance of the index was then evaluated in defined mixtures of liver and breast cancer RNA. A calibration curve was established to allow estimation of the liver RNA content in unknown metastatic breast cancer samples. A set of liver biopsies and primary breast cancer biopsies were used to identify genes that were expressed significantly higher in liver tissue. These genes were used in a liver index, which was validated in a new set of liver and primary breast cancer biopsies. A set of liver/breast cancer RNA mixtures was used to establish a calibration curve to allow quantification of liver contamination in metastatic breast cancer samples. The prediction error of the calibration curve was assessed in a new set of liver/breast cancer RNA mixtures and applied to estimate the liver content in a set of unknown metastatic breast cancer biopsies.http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-33116http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-33116/samples/