{"owner": "ArrayExpress Uploader", "pop_total": 0, "species": "human", "factors": [{"GSM814750 1": {}}, {"GSM814751 1": {}}, {"GSM814752 1": {}}, {"GSM814753 1": {}}, {"GSM814754 1": {}}, {"GSM814755 1": {}}, {"GSM814756 1": {}}, {"GSM814757 1": {}}], "id": 4262, "ownerprofile_id": "arrayexpress_sid", "platform": 4, "summary_wrapped": "Inhibiting the unfolded protein response (UPR) can be a therapeutic approach, especially for targeting the tumor microenvironment. We...", "geo_gse_id": "E-GEOD-32911", "owner_profile": "/profile/8773/arrayexpressuploader", "factor_count": 0, "sample_count": 8, "tags": ["glucose", "protein"], "lastmodified": "Dec.12, 2014", "is_default": false, "geo_id_plat": "E-GEOD-32911_A-AFFY-44", "slug": "compound-c-prevents-the-unfolded-protein-response", "geo_gds_id": "", "name": "Compound C prevents the unfolded protein response during glucose deprivation through a mechanism independent of AMPK and BMP signaling.", "created": "Sep.16, 2014", "summary": "Inhibiting the unfolded protein response (UPR) can be a therapeutic approach, especially for targeting the tumor microenvironment. We found that compound C (also known as dorsomorphin) prevented the UPR and exerted enhanced cytotoxicity during glucose deprivation. The UPR-inhibiting activity of compound C was not associated with either AMPK or BMP signaling inhibition. To induce the UPR, we treated HT1080 cells for 18 hours under ER stress conditions by adding 10 mM 2-Deoxy-D-glucose (2DG) to culture medium. UPR inhibitors (compound C, versipelostatin and phenformin) were added just before 2DG was added in medium. Total 8 samples were prepared for RNA extraction and hybridization on Affymetrix microarrays.", "source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-32911", "sample_source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-32911/samples/"}